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| H | Standard Liège | - | 1. FC Köln | 0:0 (0:0) | ||
| R | 1. FC Köln | - | Standard Liège | 3:2 (1:1) | ||
| H: 04.03.1981 | R: 18.03.1981 | Sieger: 1. FC Köln | ||||
| H | AZ '67 Alkmaar | - | Sporting Lokeren | 2:0 (2:0) | ||
| R | Sporting Lokeren | - | AZ '67 Alkmaar | 1:0 (1:0) | ||
| H: 04.03.1981 | R: 18.03.1981 | Sieger: AZ '67 Alkmaar | ||||
| H | AS Saint-Étienne | - | Ipswich Town | 1:4 (1:1) | ||
| R | Ipswich Town | - | AS Saint-Étienne | 3:1 (0:0) | ||
| H: 04.03.1981 | R: 18.03.1981 | Sieger: Ipswich Town | ||||
| H | Grasshopper Club Zürich | - | FC Sochaux | 0:0 (0:0) | ||
| R | FC Sochaux | - | Grasshopper Club Zürich | 2:1 (1:1) | ||
| H: 04.03.1981 | R: 18.03.1981 | Sieger: FC Sochaux | ||||
