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| 06.05.2022 | 19:00 | Gaziantep FK | - | Kayserispor | 1:1 (1:1) | |
| 19:00 | Hatayspor | - | Trabzonspor | 1:1 (0:0) | ||
| 07.05.2022 | 15:00 | Fatih Karagümrük | - | Göztepe | 3:1 (1:0) | |
| 15:00 | Sivasspor | - | Kasımpaşa SK | 1:3 (0:0) | ||
| 18:00 | Adana Demirspor | - | Alanyaspor | 1:2 (1:1) | ||
| 18:00 | İstanbul Başakşehir | - | Galatasaray | 0:0 (0:0) | ||
| 08.05.2022 | 15:00 | Altay Izmir | - | Giresunspor | 1:1 (0:1) | |
| 15:00 | Yeni Malatyaspor | - | Çaykur Rizespor | 1:3 (1:2) | ||
| 18:00 | Beşiktaş | - | Fenerbahçe | 1:1 (1:1) | ||
| 09.05.2022 | 19:00 | Antalyaspor | - | Konyaspor | 3:2 (2:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 36 | 22 | 12 | 2 | 66:32 | 34 | 78 |
| 2 |
|
Fenerbahçe | 36 | 20 | 9 | 7 | 68:38 | 30 | 69 |
| 3 |
|
Konyaspor | 36 | 19 | 7 | 10 | 62:43 | 19 | 64 |
| 4 |
|
İstanbul Başakşehir | 36 | 18 | 7 | 11 | 52:34 | 18 | 61 |
| 5 |
|
Alanyaspor | 36 | 17 | 7 | 12 | 63:58 | 5 | 58 |
| 6 |
|
Fatih Karagümrük | 36 | 16 | 8 | 12 | 47:51 | -4 | 56 |
| 7 |
|
Beşiktaş | 36 | 14 | 13 | 9 | 53:47 | 6 | 55 |
| 8 |
|
Antalyaspor | 36 | 15 | 10 | 11 | 49:44 | 5 | 55 |
| 9 |
|
Adana Demirspor | 36 | 14 | 10 | 12 | 51:44 | 7 | 52 |
| 10 |
|
Kasımpaşa SK | 36 | 14 | 8 | 14 | 61:51 | 10 | 50 |
| 11 |
|
Hatayspor | 36 | 14 | 8 | 14 | 51:56 | -5 | 50 |
| 12 |
|
Sivasspor | 36 | 12 | 12 | 12 | 48:48 | 0 | 48 |
| 13 |
|
Galatasaray | 36 | 13 | 9 | 14 | 47:50 | -3 | 48 |
| 14 |
|
Giresunspor | 36 | 12 | 8 | 16 | 39:42 | -3 | 44 |
| 15 |
|
Kayserispor | 36 | 11 | 11 | 14 | 50:59 | -9 | 44 |
| 16 |
|
Gaziantep FK | 36 | 11 | 10 | 15 | 46:53 | -7 | 43 |
| 17 |
|
Çaykur Rizespor | 36 | 10 | 6 | 20 | 43:67 | -24 | 36 |
| 18 |
|
Altay Izmir | 36 | 9 | 7 | 20 | 36:51 | -15 | 34 |
| 19 |
|
Göztepe | 36 | 7 | 7 | 22 | 40:68 | -28 | 28 |
| 20 |
|
Yeni Malatyaspor | 36 | 5 | 5 | 26 | 27:63 | -36 | 20 |
| Champions League | |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
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# Die Begegnung Gaziantep FK - Yeni Malatyaspor (22. Spieltag) wurde wegen starken Schneefalls in der Halbzeitpause abgebrochen. Die zweite Halbzeit wurde am 23.02.2022 gespielt. |
