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| 14.11.2021 | 11:00 | Adıyamanspor | - | Serik Belediyespor | 0:4 (0:1) | |
| 11:00 | Afjet Afyonspor | - | Turgutluspor | 4:0 (2:0) | ||
| 11:00 | Ankaraspor | - | Sarıyer SK | 2:2 (1:2) | ||
| 11:00 | Diyarbekirspor | - | Sakaryaspor | 1:2 (0:1) | ||
| 11:00 | Ergene Velimeşe | - | Etimesgut Belediyespor | 1:2 (1:0) | ||
| 11:00 | Hekimoğlu Trabzon | - | Bayburt İl Özel İdare | 1:1 (0:1) | ||
| 11:00 | Inegölspor | - | Sivas Belediyespor | 0:1 (0:0) | ||
| 11:00 | Niğde Anadolu FK | - | Kahramanmaraşspor | 1:2 (0:2) | ||
| 11:00 | Somaspor | - | Çorum FK | 1:1 (1:1) | ||
| 11:00 | Vanspor FK | - | Bodrum FK | 1:3 (1:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 13 | 8 | 5 | 0 | 24:3 | 21 | 29 |
| 2 |
|
Hekimoğlu Trabzon | 13 | 8 | 5 | 0 | 26:8 | 18 | 29 |
| 3 |
|
Sivas Belediyespor | 13 | 8 | 3 | 2 | 22:5 | 17 | 27 |
| 4 |
|
Çorum FK | 13 | 7 | 5 | 1 | 21:7 | 14 | 26 |
| 5 |
|
Bayburt İl Özel İdare | 13 | 7 | 3 | 3 | 19:12 | 7 | 24 |
| 6 |
|
Vanspor FK | 13 | 7 | 3 | 3 | 20:18 | 2 | 24 |
| 7 |
|
Bodrum FK | 13 | 7 | 2 | 4 | 22:10 | 12 | 23 |
| 8 |
|
Somaspor | 13 | 6 | 4 | 3 | 21:16 | 5 | 22 |
| 9 |
|
Ankaraspor | 13 | 6 | 3 | 4 | 25:16 | 9 | 21 |
| 10 |
|
Afjet Afyonspor | 13 | 5 | 6 | 2 | 22:15 | 7 | 21 |
| 11 |
|
Serik Belediyespor | 13 | 6 | 1 | 6 | 19:20 | -1 | 19 |
| 12 |
|
Etimesgut Belediyespor | 13 | 5 | 3 | 5 | 15:17 | -2 | 18 |
| 13 |
|
Diyarbekirspor | 13 | 4 | 3 | 6 | 14:15 | -1 | 15 |
| 14 |
|
Inegölspor | 13 | 4 | 3 | 6 | 16:21 | -5 | 15 |
| 15 |
|
Sarıyer SK | 13 | 3 | 3 | 7 | 14:22 | -8 | 12 |
| 16 |
|
Turgutluspor | 13 | 2 | 5 | 6 | 15:25 | -10 | 11 |
| 17 |
|
Ergene Velimeşe | 13 | 3 | 2 | 8 | 10:26 | -16 | 11 |
| 18 |
|
Niğde Anadolu FK | 13 | 1 | 2 | 10 | 8:32 | -24 | 5 |
| 19 |
|
Adıyamanspor | 13 | 1 | 1 | 11 | 11:29 | -18 | 4 |
| 20 |
|
Kahramanmaraşspor | 13 | 1 | 0 | 12 | 6:33 | -27 | 3 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
