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| H | Platense Zacatecoluca | - | Alianza | 1:0 (0:0) | ||
| R | Alianza | - | Platense Zacatecoluca | 3:1 (1:1) | ||
| H: 18.05.2022 22:30 | R: 22.05.2022 23:15 | Sieger: Alianza | ||||
| H | Isidro Metapán | - | CD Águila | 1:2 (0:1) | ||
| R | CD Águila | - | Isidro Metapán | 2:1 (1:0) | ||
| H: 19.05.2022 03:30 | R: 22.05.2022 03:00 | Sieger: CD Águila | ||||
