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| H | Jocoro FC | - | Alianza | 2:3 (1:2) | ||
| R | Alianza | - | Jocoro FC | 1:0 (0:0) | ||
| H: 01.12.2021 22:00 | R: 05.12.2021 22:00 | Sieger: Alianza | ||||
| H | Platense Zacatecoluca | - | Luis Ángel Firpo | 2:2 (2:1) | ||
| R | Luis Ángel Firpo | - | Platense Zacatecoluca | 1:2 (1:1) | ||
| H: 01.12.2021 22:15 | R: 05.12.2021 22:15 | Sieger: Platense Zacatecoluca | ||||
| H | CD Águila | - | Once Municipal | 1:1 (0:1) | ||
| R | Once Municipal | - | CD Águila | 4:3 (0:0, 0:0, 0:0) i.E. | ||
| H: 02.12.2021 02:00 | R: 05.12.2021 22:00 | Sieger: Once Municipal | ||||
| H | AD Chalatenango | - | FAS | 0:0 (0:0) | ||
| R | FAS | - | AD Chalatenango | 2:4 (1:0, 1:1) i.E. | ||
| H: 03.12.2021 01:30 | R: 05.12.2021 22:00 | Sieger: AD Chalatenango | ||||
