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| 19.12.2020 | 14:00 | Borussia Dortmund II | - | Wuppertaler SV | 3:0 (1:0) | |
| 14:00 | Bor. Mönchengladbach II | - | Rot-Weiß Oberhausen | 1:1 (0:0) | ||
| 14:00 | Fortuna Düsseldorf II | - | SV Bergisch Gladbach 09 | 5:2 (1:0) | ||
| 14:00 | Fortuna Köln | - | SV Rödinghausen | 3:2 (1:2) | ||
| 14:00 | Preußen Münster | - | FC Schalke 04 II | 1:1 (1:0) | ||
| 14:00 | Rot Weiss Ahlen | - | VfB Homberg | 5:1 (3:0) | ||
| 14:00 | Rot-Weiss Essen | - | FC Wegberg-Beeck | 3:2 (2:1) | ||
| 14:00 | SC Wiedenbrück | - | Sportfreunde Lotte | 0:0 (0:0) | ||
| 14:00 | SV Lippstadt 08 | - | SV 19 Straelen | 1:1 (1:1) | ||
| 27.01.2021 | 14:00 | 1. FC Köln II | - | Bonner SC | 1:1 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Rot-Weiss Essen | 20 | 15 | 5 | 0 | 46:12 | 34 | 50 |
| 2 |
|
Borussia Dortmund II | 20 | 14 | 5 | 1 | 53:15 | 38 | 47 |
| 3 |
|
Fortuna Köln | 20 | 10 | 7 | 3 | 39:23 | 16 | 37 |
| 4 |
|
Fortuna Düsseldorf II | 20 | 10 | 5 | 5 | 40:19 | 21 | 35 |
| 5 |
|
Preußen Münster | 20 | 10 | 4 | 6 | 28:19 | 9 | 34 |
| 6 |
|
1. FC Köln II | 20 | 8 | 8 | 4 | 29:20 | 9 | 32 |
| 7 |
|
Bor. Mönchengladbach II | 20 | 9 | 5 | 6 | 31:24 | 7 | 32 |
| 8 |
|
FC Schalke 04 II | 20 | 7 | 9 | 4 | 27:21 | 6 | 30 |
| 9 |
|
Alemannia Aachen | 20 | 8 | 6 | 6 | 18:15 | 3 | 30 |
| 10 |
|
SV Rödinghausen | 20 | 8 | 5 | 7 | 26:22 | 4 | 29 |
| 11 |
|
SC Wiedenbrück | 20 | 5 | 10 | 5 | 29:29 | 0 | 25 |
| 12 |
|
SV 19 Straelen | 20 | 6 | 7 | 7 | 23:32 | -9 | 25 |
| 13 |
|
Rot-Weiß Oberhausen | 20 | 5 | 9 | 6 | 26:28 | -2 | 24 |
| 14 |
|
FC Wegberg-Beeck | 20 | 5 | 6 | 9 | 22:29 | -7 | 21 |
| 15 |
|
SV Lippstadt 08 | 20 | 3 | 10 | 7 | 20:33 | -13 | 19 |
| 16 |
|
Wuppertaler SV | 20 | 5 | 4 | 11 | 21:37 | -16 | 19 |
| 17 |
|
SV Bergisch Gladbach 09 | 20 | 4 | 6 | 10 | 19:36 | -17 | 18 |
| 18 |
|
VfB Homberg | 20 | 5 | 3 | 12 | 18:38 | -20 | 18 |
| 19 |
|
Sportfreunde Lotte | 20 | 3 | 5 | 12 | 17:41 | -24 | 14 |
| 20 |
|
Rot Weiss Ahlen | 20 | 2 | 7 | 11 | 23:40 | -17 | 13 |
| 21 |
|
Bonner SC | 20 | 3 | 4 | 13 | 19:41 | -22 | 13 |
| Aufstieg | |
| Abstieg |
