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| 26.09.2021 | 15:00 | FCE Rheine | - | Holzwickeder SC | 3:0 (1:0) | |
| 15:00 | TuS Haltern | - | TuS Erndtebrück | 1:1 (0:0) | ||
| 15:00 | SG Wattenscheid 09 | - | ASC 09 Dortmund | 0:2 (0:1) | ||
| 15:00 | SV Schermbeck | - | SG Finnentrop/Bamenohl | 4:1 (2:0) | ||
| 15:00 | SpVgg Vreden | - | SC Paderborn 07 II | 0:5 (0:1) | ||
| 15:00 | Hammer SpVg | - | Westfalia Herne | 4:0 (1:0) | ||
| 15:00 | TSG Sprockhövel | - | Westfalia Rhynern | 5:0 (1:0) | ||
| 15:00 | Sportfreunde Siegen | - | RSV Meinerzhagen | 3:1 (2:0) | ||
| 15:00 | FC Gütersloh | - | Preußen Münster II | 4:1 (3:1) | ||
| 15:15 | TuS Ennepetal | - | 1. FC Kaan-Marienborn | 0:3 (0:3) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Paderborn 07 II | 5 | 4 | 0 | 1 | 15:3 | 12 | 12 |
| 2 |
|
SG Wattenscheid 09 | 5 | 4 | 0 | 1 | 12:8 | 4 | 12 |
| 3 |
|
FCE Rheine | 5 | 4 | 0 | 1 | 7:4 | 3 | 12 |
| 4 |
|
1. FC Kaan-Marienborn | 4 | 3 | 1 | 0 | 15:4 | 11 | 10 |
| 5 |
|
TSG Sprockhövel | 5 | 3 | 1 | 1 | 14:6 | 8 | 10 |
| 6 |
|
ASC 09 Dortmund | 5 | 3 | 1 | 1 | 13:9 | 4 | 10 |
| 7 |
|
SV Schermbeck | 5 | 2 | 1 | 2 | 14:10 | 4 | 7 |
| 8 |
|
FC Gütersloh | 4 | 2 | 1 | 1 | 6:4 | 2 | 7 |
| 9 |
|
TuS Ennepetal | 5 | 2 | 1 | 2 | 12:13 | -1 | 7 |
| 10 |
|
Preußen Münster II | 5 | 2 | 1 | 2 | 9:10 | -1 | 7 |
| 11 |
|
Hammer SpVg | 5 | 2 | 0 | 3 | 11:9 | 2 | 6 |
| 12 |
|
TuS Haltern | 4 | 1 | 3 | 0 | 4:2 | 2 | 6 |
| 13 |
|
Westfalia Rhynern | 5 | 2 | 0 | 3 | 11:11 | 0 | 6 |
| 14 |
|
TuS Erndtebrück | 5 | 1 | 3 | 1 | 8:9 | -1 | 6 |
| 15 |
|
Holzwickeder SC | 5 | 2 | 0 | 3 | 8:13 | -5 | 6 |
| 16 |
|
Sportfreunde Siegen | 5 | 1 | 2 | 2 | 7:9 | -2 | 5 |
| 17 |
|
RSV Meinerzhagen | 5 | 1 | 0 | 4 | 7:14 | -7 | 3 |
| 18 |
|
Viktoria Clarholz | 4 | 0 | 2 | 2 | 7:11 | -4 | 2 |
| 19 |
|
SG Finnentrop/Bamenohl | 4 | 0 | 2 | 2 | 5:14 | -9 | 2 |
| 20 |
|
SpVgg Vreden | 5 | 0 | 2 | 3 | 4:13 | -9 | 2 |
| 21 |
|
Westfalia Herne | 5 | 0 | 1 | 4 | 2:15 | -13 | 1 |
| Playoffs | |
| Relegation |
