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| 08.05.2022 | 15:00 | SV 1914 Eilendorf | - | SV Breinig | 0:0 (0:0) | |
| 15:00 | FC Hürth | - | 1. FC Düren | 1:1 (0:0) | ||
| 15:00 | Viktoria Arnoldsweiler | - | Spvg Wesseling-Urfeld | 6:0 (1:0) | ||
| 15:00 | SV Bergisch Gladbach 09 | - | BC Viktoria Glesch-Paffendorf | 6:0 (2:0) | ||
| 15:00 | FC Hennef 05 | - | Fortuna Köln II | 4:3 (1:0) | ||
| 15:00 | Borussia Freialdenhoven | - | VfL Alfter | 2:1 (0:0) | ||
| 15:30 | Blau-Weiß Friesdorf | - | FC Pesch 1956 | 3:3 (0:1) | ||
| 15:30 | VfL 08 Vichttal | - | Siegburger SV 04 | 2:1 (1:1) | ||
| 15:30 | SpVg Frechen 20 | - | SV Deutz 05 | 3:1 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Düren | 29 | 23 | 5 | 1 | 89:19 | 70 | 74 |
| 2 |
|
FC Hennef 05 | 29 | 21 | 4 | 4 | 72:26 | 46 | 67 |
| 3 |
|
SV Bergisch Gladbach 09 | 29 | 19 | 8 | 2 | 73:19 | 54 | 65 |
| 4 |
|
SpVg Frechen 20 | 29 | 18 | 5 | 6 | 63:32 | 31 | 59 |
| 5 |
|
Borussia Freialdenhoven | 29 | 15 | 5 | 9 | 53:43 | 10 | 50 |
| 6 |
|
Blau-Weiß Friesdorf | 29 | 12 | 8 | 9 | 58:46 | 12 | 44 |
| 7 |
|
Siegburger SV 04 | 29 | 11 | 9 | 9 | 50:40 | 10 | 42 |
| 8 |
|
FC Pesch 1956 | 29 | 10 | 11 | 8 | 61:47 | 14 | 41 |
| 9 |
|
Viktoria Arnoldsweiler | 29 | 13 | 2 | 14 | 52:47 | 5 | 41 |
| 10 |
|
FC Hürth | 29 | 12 | 5 | 12 | 43:54 | -11 | 41 |
| 11 |
|
VfL 08 Vichttal | 29 | 11 | 5 | 13 | 50:62 | -12 | 38 |
| 12 |
|
VfL Alfter | 29 | 11 | 4 | 14 | 45:50 | -5 | 37 |
| 13 |
|
BC Viktoria Glesch-Paffendorf | 29 | 10 | 6 | 13 | 39:43 | -4 | 36 |
| 14 |
|
SV 1914 Eilendorf | 29 | 8 | 5 | 16 | 31:53 | -22 | 29 |
| 15 |
|
Fortuna Köln II | 29 | 7 | 6 | 16 | 44:61 | -17 | 27 |
| 16 |
|
SV Deutz 05 | 29 | 5 | 3 | 21 | 30:70 | -40 | 18 |
| 17 |
|
SV Breinig | 29 | 5 | 3 | 21 | 35:84 | -49 | 18 |
| 18 |
|
Spvg Wesseling-Urfeld | 29 | 3 | 0 | 26 | 25:117 | -92 | 9 |
| Playoffs | |
| Abstieg |
