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| 13.09.2022 | 20:45 | Ballyclare Comrades | - | Ballinamallard United FC | 4:2 n.V. | |
| 20:45 | Bangor FC | - | Annagh United | 0:4 | ||
| 20:45 | Carrick Rangers | - | Banbridge Town | 5:0 | ||
| 20:45 | Coleraine FC | - | Dergview FC | 4:0 | ||
| 20:45 | Dundela FC | - | Crusaders FC | 2:1 | ||
| 20:45 | Dungannon Swifts | - | Queen's University Belfast | 3:0 | ||
| 20:45 | Glenavon FC | - | Dollingstown FC | 6:0 | ||
| 20:45 | H&W Welders | - | Cliftonville FC | 0:3 | ||
| 20:45 | Larne FC | - | Lisburn Distillery | 5:1 | ||
| 20:45 | Limavady United | - | Newry City FC | 4:5 i.E. | ||
| 20:45 | Loughgall FC | - | Knockbreda FC | 5:0 | ||
| 20:45 | Moyola Park FC | - | Linfield FC | 1:5 | ||
| 20:45 | Portadown FC | - | Armagh City FC | 5:0 | ||
| 20:45 | Warrenpoint Town | - | Newington FC | 1:0 | ||
| 21:00 | Glentoran FC | - | Institute FC Drumahoe | 7:0 | ||
| 14.09.2022 | 20:45 | Ards FC | - | Ballymena United | 2:4 n.V. |
