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| 01.04.2022 | 19:30 | PSV Eindhoven | - | sc Heerenveen | 1:0 (0:0) | |
| 19:30 | ADO Den Haag | - | PEC Zwolle | 2:0 (0:0) | ||
| 19:30 | vv Alkmaar | - | Feyenoord | 1:3 (1:0) | ||
| 19:30 | SBV Excelsior | - | FC Twente | 0:5 (0:4) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Twente | 19 | 14 | 3 | 2 | 76:23 | 53 | 45 |
| 2 |
|
AFC Ajax | 19 | 13 | 3 | 3 | 47:16 | 31 | 42 |
| 3 |
|
Feyenoord | 19 | 10 | 4 | 5 | 28:25 | 3 | 34 |
| 4 |
|
PSV Eindhoven | 19 | 10 | 3 | 6 | 27:22 | 5 | 33 |
| 5 |
|
ADO Den Haag | 20 | 8 | 6 | 6 | 34:25 | 9 | 30 |
| 6 |
|
PEC Zwolle | 20 | 8 | 2 | 10 | 30:34 | -4 | 26 |
| 7 |
|
vv Alkmaar | 20 | 5 | 1 | 14 | 24:51 | -27 | 16 |
| 8 |
|
sc Heerenveen | 20 | 3 | 5 | 12 | 18:40 | -22 | 14 |
| 9 |
|
SBV Excelsior | 20 | 2 | 3 | 15 | 20:68 | -48 | 9 |
| Champions League |
