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| 01.04.2022 | 20:00 | Almere City FC | - | SBV Excelsior | 3:0 (0:0) | |
| 20:00 | De Graafschap | - | FC Emmen | 1:1 (1:1) | ||
| 20:00 | FC Dordrecht | - | FC Eindhoven | 0:1 (0:1) | ||
| 20:00 | FC Volendam | - | TOP Oss | 1:2 (0:1) | ||
| 20:00 | Helmond Sport | - | MVV | 1:2 (1:0) | ||
| 20:00 | AZ Alkmaar (J) | - | Jong PSV | 2:0 (1:0) | ||
| 20:00 | NAC Breda | - | Jong Ajax | 0:0 (0:0) | ||
| 20:00 | Roda JC Kerkrade | - | FC Utrecht (J) | 2:1 (1:0) | ||
| 20:00 | Telstar | - | FC Den Bosch | 1:2 (0:1) | ||
| 20:00 | VVV-Venlo | - | ADO Den Haag | 0:5 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Emmen | 33 | 22 | 5 | 6 | 55:23 | 32 | 71 |
| 2 |
|
FC Volendam | 33 | 18 | 11 | 4 | 69:45 | 24 | 65 |
| 3 |
|
SBV Excelsior | 33 | 19 | 5 | 9 | 73:45 | 28 | 62 |
| 4 |
|
FC Eindhoven | 33 | 18 | 7 | 8 | 61:37 | 24 | 61 |
| 5 |
|
Roda JC Kerkrade | 33 | 16 | 11 | 6 | 66:39 | 27 | 59 |
| 6 |
|
Jong Ajax | 33 | 17 | 7 | 9 | 72:55 | 17 | 58 |
| 7 |
|
ADO Den Haag | 33 | 19 | 6 | 8 | 71:48 | 23 | 57 |
| 8 |
|
De Graafschap | 33 | 14 | 9 | 10 | 44:36 | 8 | 51 |
| 9 |
|
NAC Breda | 33 | 13 | 10 | 10 | 49:39 | 10 | 49 |
| 10 |
|
VVV-Venlo | 33 | 12 | 5 | 16 | 40:49 | -9 | 41 |
| 11 |
|
Jong PSV | 33 | 10 | 8 | 15 | 54:56 | -2 | 38 |
| 12 |
|
Almere City FC | 33 | 10 | 8 | 15 | 52:58 | -6 | 38 |
| 13 |
|
AZ Alkmaar (J) | 33 | 11 | 5 | 17 | 33:42 | -9 | 38 |
| 14 |
|
FC Den Bosch | 33 | 11 | 4 | 18 | 35:58 | -23 | 37 |
| 15 |
|
TOP Oss | 33 | 9 | 8 | 16 | 42:54 | -12 | 35 |
| 16 |
|
FC Dordrecht | 33 | 8 | 8 | 17 | 47:69 | -22 | 32 |
| 17 |
|
Telstar | 33 | 7 | 11 | 15 | 37:62 | -25 | 32 |
| 18 |
|
MVV | 33 | 10 | 2 | 21 | 36:68 | -32 | 32 |
| 19 |
|
FC Utrecht (J) | 33 | 9 | 4 | 20 | 33:59 | -26 | 31 |
| 20 |
|
Helmond Sport | 33 | 7 | 6 | 20 | 33:60 | -27 | 24 |
| Aufstieg | |
| Playoffs | |
| Playoffs |
|
# ADO Den Haag: -6 P. # Helmond Sport: -3 P. |
