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| H | FK Rabotnički | - | Sileks Kratovo | 3:0 (0:0) | ||
| R | Sileks Kratovo | - | FK Rabotnički | 1:2 (0:1) | ||
| H: 25.11.2015 13:00 | R: 02.12.2015 13:00 | Sieger: FK Rabotnički | ||||
| H | Mladost Carev Dvor | - | FK Bregalnica Štip | 1:1 (1:0) | ||
| R | FK Bregalnica Štip | - | Mladost Carev Dvor | 4:1 (2:0) | ||
| H: 25.11.2015 13:00 | R: 02.12.2015 13:00 | Sieger: FK Bregalnica Štip | ||||
| H | Makedonija GP | - | FK Turnovo | 2:4 (0:1) | ||
| R | FK Turnovo | - | Makedonija GP | 0:1 (0:1) | ||
| H: 25.11.2015 13:00 | R: 02.12.2015 13:00 | Sieger: FK Turnovo | ||||
| H | KF Shkëndija 79 | - | Vardar Skopje | 3:0 (2:0) | ||
| R | Vardar Skopje | - | KF Shkëndija 79 | 1:2 (0:1) | ||
| H: 26.11.2015 13:00 | R: 02.12.2015 13:00 | Sieger: KF Shkëndija 79 | ||||
