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| 29.10.2021 | 14:00 | KF Shkupi | - | FK Bregalnica Štip | 5:0 (3:0) | |
| 30.10.2021 | 14:00 | FK Borec | - | FK Rabotnički | 0:1 (0:0) | |
| 14:00 | FK Pelister | - | Makedonija GP | 0:2 (0:2) | ||
| 14:00 | FK Skopje | - | FK Renova | 0:0 (0:0) | ||
| 14:00 | KF Shkëndija 79 | - | GFK Tikvesh | 1:1 (1:0) | ||
| 14:00 | FC Struga | - | FK AP Brera Strumica | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 12 | 9 | 2 | 1 | 26:7 | 19 | 29 |
| 2 |
|
FK Renova | 12 | 6 | 4 | 2 | 19:10 | 9 | 22 |
| 3 |
|
FK AP Brera Strumica | 12 | 6 | 4 | 2 | 18:11 | 7 | 22 |
| 4 |
|
FK Bregalnica Štip | 12 | 5 | 4 | 3 | 19:19 | 0 | 19 |
| 5 |
|
KF Shkëndija 79 | 12 | 4 | 6 | 2 | 20:11 | 9 | 18 |
| 6 |
|
FK Rabotnički | 12 | 5 | 3 | 4 | 10:10 | 0 | 18 |
| 7 |
|
FC Struga | 12 | 3 | 7 | 2 | 11:9 | 2 | 16 |
| 8 |
|
FK Skopje | 12 | 4 | 4 | 4 | 9:14 | -5 | 16 |
| 9 |
|
Makedonija GP | 12 | 4 | 2 | 6 | 15:24 | -9 | 14 |
| 10 |
|
FK Borec | 12 | 2 | 2 | 8 | 9:21 | -12 | 8 |
| 11 |
|
GFK Tikvesh | 12 | 1 | 4 | 7 | 8:15 | -7 | 7 |
| 12 |
|
FK Pelister | 12 | 0 | 4 | 8 | 4:17 | -13 | 4 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
