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| H | Club León | - | CF América | 0:1 (0:0) | ||
| R | CF América | - | Club León | 3:3 (1:0) | ||
| H: 05.10.2022 16:00 | R: 08.10.2022 16:00 | Sieger: CF América | ||||
| H | Puebla FC | - | Atlas Guadalajara | 0:0 (0:0) | ||
| R | Atlas Guadalajara | - | Puebla FC | 1:1 (0:0) | ||
| H: 05.10.2022 17:00 | R: 08.10.2022 16:00 | Sieger: Puebla FC | ||||
| H | Pumas UNAM | - | UANL Tigres | 3:1 (1:1) | ||
| R | UANL Tigres | - | Pumas UNAM | 1:2 (1:1) | ||
| H: 05.10.2022 17:00 | R: 08.10.2022 18:15 | Sieger: Pumas UNAM | ||||
| H | Santos Laguna | - | CF Pachuca | 0:0 (0:0) | ||
| R | CF Pachuca | - | Santos Laguna | 1:0 (0:0) | ||
| H: 06.10.2022 18:00 | R: 09.10.2022 19:00 | Sieger: CF Pachuca | ||||
