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| H | Atlas Guadalajara | - | CF Monterrey | 2:1 (1:1) | ||
| R | CF Monterrey | - | Atlas Guadalajara | 2:0 (1:0) | ||
| H: 03.05.2023 17:00 | R: 06.05.2023 19:30 | Sieger: CF Monterrey | ||||
| H | CF América | - | Cruz Azul | 2:1 (2:0) | ||
| R | Cruz Azul | - | CF América | 3:0 (2:0) | ||
| H: 03.05.2023 19:00 | R: 06.05.2023 17:30 | Sieger: Cruz Azul | ||||
| H | Deportivo Guadalajara | - | UANL Tigres | 1:0 (1:0) | ||
| R | UANL Tigres | - | Deportivo Guadalajara | 1:2 (1:0) | ||
| H: 04.05.2023 17:00 | R: 07.05.2023 18:00 | Sieger: Deportivo Guadalajara | ||||
| H | Deportivo Toluca | - | Club Necaxa | 1:0 (0:0) | ||
| R | Club Necaxa | - | Deportivo Toluca | 2:1 (0:1) | ||
| H: 04.05.2023 19:30 | R: 07.05.2023 18:00 | Sieger: Deportivo Toluca | ||||
