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| 04.02.2022 | 16:00 | Atlético San Luis | - | Santos Laguna | 2:1 (2:0) | |
| 05.02.2022 | 16:00 | Deportivo Toluca | - | Cruz Azul | 0:4 (0:2) | |
| 16:00 | Gallos Blancos | - | FC Juárez | 2:1 (1:0) | ||
| 16:00 | CF Monterrey | - | Club León | 0:1 (0:0) | ||
| 17:00 | Pumas UNAM | - | CF Pachuca | 4:0 (2:0) | ||
| 19:00 | Club Necaxa | - | Puebla FC | 0:0 (0:0) | ||
| 19:00 | Club Tijuana | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| 19:30 | Mazatlán FC | - | UANL Tigres | 2:2 (0:1) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 5 | 4 | 0 | 1 | 13:5 | 8 | 12 |
| 2 |
|
CF América | 4 | 4 | 0 | 0 | 8:0 | 8 | 12 |
| 3 |
|
Deportivo Toluca | 5 | 2 | 1 | 2 | 12:10 | 2 | 7 |
| 4 |
|
Pumas UNAM | 5 | 2 | 0 | 3 | 8:5 | 3 | 6 |
| 5 |
|
Puebla FC | 4 | 1 | 2 | 1 | 4:3 | 1 | 5 |
| 6 |
|
Club Necaxa | 4 | 1 | 2 | 1 | 4:9 | -5 | 5 |
| 7 |
|
FC Juárez | 4 | 1 | 1 | 2 | 5:7 | -2 | 4 |
| 8 |
|
Gallos Blancos | 5 | 1 | 1 | 3 | 4:10 | -6 | 4 |
| 9 |
|
CF Pachuca | 4 | 0 | 1 | 3 | 4:13 | -9 | 1 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 5 | 3 | 2 | 0 | 7:4 | 3 | 11 |
| 2 |
|
Atlas Guadalajara | 4 | 3 | 1 | 0 | 7:2 | 5 | 10 |
| 3 |
|
UANL Tigres | 4 | 2 | 1 | 1 | 6:4 | 2 | 7 |
| 4 |
|
Mazatlán FC | 4 | 1 | 2 | 1 | 6:6 | 0 | 5 |
| 5 |
|
Santos Laguna | 4 | 1 | 1 | 2 | 3:3 | 0 | 4 |
| 6 |
|
CF Monterrey | 5 | 0 | 4 | 1 | 6:7 | -1 | 4 |
| 7 |
|
Club León | 4 | 1 | 1 | 2 | 4:5 | -1 | 4 |
| 8 |
|
Atlético San Luis | 5 | 1 | 1 | 3 | 4:7 | -3 | 4 |
| 9 |
|
Club Tijuana | 5 | 1 | 1 | 3 | 4:9 | -5 | 4 |
| Playoffs | |
| Playoffs |
