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| H | Club León | - | CF América | 1:1 (1:0) | ||
| R | CF América | - | Club León | 4:1 (1:0) | ||
| H: 02.05.2001 | R: 05.05.2001 | Sieger: CF América | ||||
| H | CF Pachuca | - | CF Monterrey | 4:0 (1:0) | ||
| R | CF Monterrey | - | CF Pachuca | 2:2 (1:0) | ||
| H: 02.05.2001 | R: 05.05.2001 | Sieger: CF Pachuca | ||||
| H | Puebla FC | - | UANL Tigres | 3:1 (0:1) | ||
| R | UANL Tigres | - | Puebla FC | 2:2 (0:0) | ||
| H: 02.05.2001 | R: 05.05.2001 | Sieger: Puebla FC | ||||
| H | UAG Tecos | - | Santos Laguna | 2:3 (1:1) | ||
| R | Santos Laguna | - | UAG Tecos | 4:0 (1:0) | ||
| H: 03.05.2001 | R: 06.05.2001 | Sieger: Santos Laguna | ||||
