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| H | Alacranes de Durango | - | Cafetaleros de Chiapas | 1:1 (1:0) | ||
| R | Cafetaleros de Chiapas | - | Alacranes de Durango | 1:0 (0:0) | ||
| H: 16.04.2022 03:00 | R: 24.04.2022 02:00 | Sieger: Cafetaleros de Chiapas | ||||
| H | Coras de Nayarit | - | Inter Playa | 1:2 (1:0) | ||
| R | Inter Playa | - | Coras de Nayarit | 1:1 (1:0) | ||
| H: 16.04.2022 04:30 | R: 22.04.2022 23:00 | Sieger: Inter Playa | ||||
| H | Escorpiones | - | Mazorqueros | 1:2 (1:0) | ||
| R | Mazorqueros | - | Escorpiones | 7:0 (3:0) | ||
| H: 16.04.2022 23:00 | R: 24.04.2022 00:30 | Sieger: Mazorqueros | ||||
| H | Yalmakan FC | - | Tritones Vallarta | 0:1 (0:0) | ||
| R | Tritones Vallarta | - | Yalmakan FC | 1:1 (0:1) | ||
| H: 17.04.2022 23:00 | R: 23.04.2022 23:30 | Sieger: Tritones Vallarta | ||||
