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| H | Atlante | - | Atlético Morelia | 0:0 (0:0) | ||
| R | Atlético Morelia | - | Atlante | 1:0 (0:0) | ||
| H: 05.05.2022 04:00 | R: 08.05.2022 00:00 | Sieger: Atlético Morelia | ||||
| H | Cimarrones de Sonora | - | Club Celaya | 1:0 (0:0) | ||
| R | Club Celaya | - | Cimarrones de Sonora | 1:1 (1:0) | ||
| H: 06.05.2022 04:00 | R: 08.05.2022 23:00 | Sieger: Cimarrones de Sonora | ||||
