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| 25.09.2021 | 18:30 | Cruz Azul | - | CF Pachuca | 3:6 (1:3) | |
| 18:30 | Gallos Blancos | - | CF América | 2:3 (0:2) | ||
| 18:30 | Club León | - | UANL Tigres | 2:1 (0:0) | ||
| 18:30 | CF Monterrey | - | Mazatlán FC | 4:1 (2:1) | ||
| 18:30 | Santos Laguna | - | Atlas Guadalajara | 2:0 (2:0) | ||
| 18:30 | Puebla FC | - | Deportivo Toluca | 2:1 (0:0) | ||
| 19:00 | Deportivo Guadalajara | - | Atlético San Luis | 4:2 (2:0) | ||
| 19:00 | Pumas UNAM | - | FC Juárez | 5:0 (2:0) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 2 | 2 | 0 | 0 | 11:3 | 8 | 6 |
| 2 |
|
Pumas UNAM | 2 | 2 | 0 | 0 | 7:1 | 6 | 6 |
| 3 |
|
CF América | 2 | 2 | 0 | 0 | 7:4 | 3 | 6 |
| 4 |
|
Puebla FC | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 |
| 5 |
|
FC Juárez | 2 | 1 | 0 | 1 | 1:5 | -4 | 3 |
| 6 |
|
Gallos Blancos | 1 | 0 | 0 | 1 | 2:3 | -1 | 0 |
| 7 |
|
Club Tijuana | 1 | 0 | 0 | 1 | 1:2 | -1 | 0 |
| 8 |
|
Cruz Azul | 2 | 0 | 0 | 2 | 5:10 | -5 | 0 |
| 9 |
|
Deportivo Toluca | 2 | 0 | 0 | 2 | 1:7 | -6 | 0 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club León | 2 | 1 | 1 | 0 | 4:3 | 1 | 4 |
| 2 |
|
UANL Tigres | 2 | 1 | 0 | 1 | 6:2 | 4 | 3 |
| 3 |
|
Club Necaxa | 1 | 1 | 0 | 0 | 4:0 | 4 | 3 |
| 4 |
|
CF Monterrey | 1 | 1 | 0 | 0 | 4:1 | 3 | 3 |
| 5 |
|
Deportivo Guadalajara | 2 | 1 | 0 | 1 | 6:6 | 0 | 3 |
| 6 |
|
Atlas Guadalajara | 2 | 1 | 0 | 1 | 4:4 | 0 | 3 |
| 7 |
|
Santos Laguna | 2 | 1 | 0 | 1 | 2:4 | -2 | 3 |
| 8 |
|
Mazatlán FC | 2 | 0 | 1 | 1 | 3:6 | -3 | 1 |
| 9 |
|
Atlético San Luis | 2 | 0 | 0 | 2 | 2:9 | -7 | 0 |
