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| H | CF Pachuca | - | Deportivo Guadalajara | 2:4 (1:0) | ||
| R | Deportivo Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| H: 21.05.2022 04:00 | R: 24.05.2022 03:05 | Sieger: Deportivo Guadalajara | ||||
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| H | CF Pachuca | - | Deportivo Guadalajara | 2:4 (1:0) | ||
| R | Deportivo Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| H: 21.05.2022 04:00 | R: 24.05.2022 03:05 | Sieger: Deportivo Guadalajara | ||||
