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| H | Dinamo-Auto | - | FC Sfîntul Gheorghe | 0:3 (0:2) | ||
| R | FC Sfîntul Gheorghe | - | Dinamo-Auto | 1:2 (1:1) | ||
| H: 26.09.2018 14:30 | R: 31.10.2018 12:00 | Sieger: FC Sfîntul Gheorghe | ||||
| H | FC Zaria | - | FC Zimbru | 3:2 (0:1) | ||
| R | FC Zimbru | - | FC Zaria | 7:1 (3:0) | ||
| H: 26.09.2018 14:30 | R: 31.10.2018 12:00 | Sieger: FC Zimbru | ||||
| H | FC Sheriff | - | Speranţa Nisporeni | 3:0 (2:0) | ||
| R | Speranţa Nisporeni | - | FC Sheriff | 0:3 (0:0) | ||
| H: 26.09.2018 17:00 | R: 31.10.2018 12:00 | Sieger: FC Sheriff | ||||
| H | CS Petrocub | - | FC Milsami | 0:2 (0:1) | ||
| R | FC Milsami | - | CS Petrocub | 0:1 (0:0) | ||
| H: 26.09.2018 17:30 | R: 31.10.2018 17:00 | Sieger: FC Milsami | ||||
