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| 07.10.2010 | 20:00 | SC Bettembourg | - | AS Colmar-Berg | 2:3 | |
| 09.10.2010 | 16:30 | CS Bourscheid | - | Orania Vianden | 2:0 | |
| 10.10.2010 | 15:00 | UNA Strassen | - | FC Ehlerange | 4:1 | |
| 15:00 | FC Schifflange 95 | - | FC Munsbach | 3:2 | ||
| 15:00 | AS Hosingen | - | US Esch | 2:1 | ||
| 15:00 | FC Noertzange HF | - | ES Schouweiler | 2:1 | ||
| 15:00 | AS Wincrange | - | Sporting Mertzig | 2:3 | ||
| 15:00 | The Belval Belvaux | - | Jeunesse Biwer | 5:0 | ||
| 15:00 | Sporting Bertrange | - | US Mertert/Wasserbillig | 2:3 | ||
| 15:00 | Jeunesse Junglinster | - | FC Lorentzweiler | 3:1 | ||
| 15:00 | Marisca Mersch | - | FC Brouch | 6:3 | ||
| 15:00 | US Sandweiler | - | CS Muhlenbach | 2:3 | ||
| 15:00 | FC Rodange 91 | - | Daring Club Echternach | 8:6 i.E. | ||
| 15:00 | FC Pratzerthal/Rédange | - | Jeunesse Schieren | 0:1 | ||
| 15:00 | FF Norden 02 | - | FC Flaxweiler/Beyren | 1:4 | ||
| 15:00 | FC Kehlen | - | Alliance Aischdall | 3:0 | ||
| 15:00 | CeBra 01 | - | CS Sanem | 1:2 | ||
| 15:00 | Berdenia Berburg | - | FC Red-Black/Egalite 07 | 4:2 | ||
| 15:00 | Résidence Walferdange | - | FC Mamer 32 | 4:5 | ||
| 16:00 | FC Atert Bissen | - | FC Kopstal | 5:1 | ||
| 16:30 | ES Clemency | - | Tricolore Gasperich | 0:2 | ||
| 17:00 | Olympia Christnach | - | US Berdorf | 1:2 |
