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| 04.12.2021 | 15:00 | AC Milan | - | US Salernitana 1919 | 2:0 (2:0) | |
| 18:00 | AS Roma | - | Inter | 0:3 (0:3) | ||
| 20:45 | SSC Napoli | - | Atalanta | 2:3 (1:1) | ||
| 05.12.2021 | 12:30 | Bologna FC | - | ACF Fiorentina | 2:3 (1:1) | |
| 15:00 | Venezia FC | - | Hellas Verona | 3:4 (3:0) | ||
| 15:00 | Spezia Calcio | - | Sassuolo Calcio | 2:2 (1:0) | ||
| 18:00 | Sampdoria | - | Lazio Roma | 1:3 (0:3) | ||
| 20:45 | Juventus | - | Genoa CFC | 2:0 (1:0) | ||
| 06.12.2021 | 18:30 | Empoli FC | - | Udinese Calcio | 3:1 (0:1) | |
| 20:45 | Cagliari Calcio | - | Torino FC | 1:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AC Milan | 16 | 12 | 2 | 2 | 35:18 | 17 | 38 |
| 2 |
|
Inter | 16 | 11 | 4 | 1 | 39:15 | 24 | 37 |
| 3 |
|
SSC Napoli | 16 | 11 | 3 | 2 | 34:12 | 22 | 36 |
| 4 |
|
Atalanta | 16 | 10 | 4 | 2 | 35:19 | 16 | 34 |
| 5 |
|
Juventus | 16 | 8 | 3 | 5 | 22:16 | 6 | 27 |
| 6 |
|
ACF Fiorentina | 16 | 9 | 0 | 7 | 27:22 | 5 | 27 |
| 7 |
|
AS Roma | 16 | 8 | 1 | 7 | 24:19 | 5 | 25 |
| 8 |
|
Lazio Roma | 16 | 7 | 4 | 5 | 32:30 | 2 | 25 |
| 9 |
|
Bologna FC | 16 | 7 | 3 | 6 | 23:27 | -4 | 24 |
| 10 |
|
Hellas Verona | 16 | 6 | 5 | 5 | 32:28 | 4 | 23 |
| 11 |
|
Empoli FC | 16 | 7 | 2 | 7 | 26:29 | -3 | 23 |
| 12 |
|
Sassuolo Calcio | 16 | 5 | 5 | 6 | 26:25 | 1 | 20 |
| 13 |
|
Torino FC | 16 | 5 | 4 | 7 | 20:17 | 3 | 19 |
| 14 |
|
Udinese Calcio | 16 | 3 | 7 | 6 | 21:27 | -6 | 16 |
| 15 |
|
Sampdoria | 16 | 4 | 3 | 9 | 22:32 | -10 | 15 |
| 16 |
|
Venezia FC | 16 | 4 | 3 | 9 | 15:29 | -14 | 15 |
| 17 |
|
Spezia Calcio | 16 | 3 | 3 | 10 | 17:36 | -19 | 12 |
| 18 |
|
Cagliari Calcio | 16 | 1 | 7 | 8 | 17:30 | -13 | 10 |
| 19 |
|
Genoa CFC | 16 | 1 | 7 | 8 | 17:31 | -14 | 10 |
| 20 |
|
US Salernitana 1919 | 16 | 2 | 2 | 12 | 11:33 | -22 | 8 |
| Champions League | |
| Europa League | |
| Europa Conference League Quali. | |
| Abstieg |
