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| 15.12.2015 | 19:15 | Genoa CFC | - | US Alessandria 1912 | 1:2 (0:0, 1:1) n.V. | |
| 21:00 | Inter | - | Cagliari Calcio | 3:0 (1:0) | ||
| 16.12.2015 | 14:30 | AS Roma | - | Spezia Calcio | 2:4 (0:0, 0:0, 0:0) i.E. | |
| 16:30 | ACF Fiorentina | - | Carpi FC | 0:1 (0:0) | ||
| 19:00 | SSC Napoli | - | Hellas Verona | 3:0 (2:0) | ||
| 20:45 | Juventus | - | Torino FC | 4:0 (1:0) | ||
| 17.12.2015 | 16:00 | Lazio Roma | - | Udinese Calcio | 2:1 (0:0) | |
| 21:00 | Sampdoria | - | AC Milan | 0:2 (0:0) |
