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| H | Panetolikos | - | Olympiakos Piraeus | 2:1 (1:1) | ||
| R | Olympiakos Piraeus | - | Panetolikos | 3:1 (1:0, 2:1) n.V. | ||
| H: 19.01.2022 14:00 | R: 09.02.2022 17:00 | Sieger: Olympiakos Piraeus | ||||
| H | Panathinaikos | - | Anagennisi Karditsa | 4:0 (4:0) | ||
| R | Anagennisi Karditsa | - | Panathinaikos | 0:1 (0:0) | ||
| H: 19.01.2022 16:00 | R: 09.02.2022 15:00 | Sieger: Panathinaikos | ||||
| H | PAOK Saloniki | - | AEK Athen | 0:0 (0:0) | ||
| R | AEK Athen | - | PAOK Saloniki | 1:2 (0:0) | ||
| H: 19.01.2022 18:00 | R: 09.02.2022 19:00 | Sieger: PAOK Saloniki | ||||
| H | Aris Saloniki | - | Lamia | 0:0 (0:0) | ||
| R | Lamia | - | Aris Saloniki | 1:0 (0:0, 0:0) n.V. | ||
| H: 20.01.2022 20:30 | R: 26.01.2022 19:00 | Sieger: Lamia | ||||
