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| 23.03.2022 | 18:00 | Feyenoord | - | RKC Waalwijk | 3:3 (1:2) | |
| 18:00 | Siegburger SV 04 | - | 1. FC Köln | 1:8 | ||
| 24.03.2022 | 13:00 | Fortuna Düsseldorf | - | FC Twente | 4:0 (3:0) | |
| 13:00 | AZ Alkmaar | - | Go Ahead Eagles | 7:1 (3:1) | ||
| 13:30 | Willem II | - | Jong PSV | 1:2 (0:1) | ||
| 14:00 | Eintracht Frankfurt | - | 1. FC Nürnberg | 1:1 (1:0) | ||
| 14:00 | sc Heerenveen | - | PEC Zwolle | 1:0 (1:0) | ||
| 14:00 | Hamburger SV | - | Viborg FF | 4:5 (0:5) | ||
| 14:00 | FC Schalke 04 | - | FC Utrecht | 1:0 | ||
| 15:00 | FC St. Gallen | - | FC Dornbirn | 9:0 (5:0) | ||
| 15:00 | FC Ingolstadt 04 | - | Wacker Burghausen | 3:1 (2:1) | ||
| 15:00 | VfB Stuttgart | - | SV Sandhausen | 2:3 | ||
| 16:00 | Dynamo Dresden | - | Slovan Liberec | 2:1 (1:0) | ||
| 18:00 | Karlsruher SC | - | FC Basel 1893 | 6:1 (2:1) | ||
| 25.03.2022 | 13:00 | VfL Bochum | - | Heracles Almelo | 2:0 (0:0) | |
| 13:00 | Jahn Regensburg | - | SpVgg Greuther Fürth | 0:3 (0:2) | ||
| 13:30 | Halmstads BK | - | IF Elfsborg | 0:4 (0:2) | ||
| 15:00 | AZ Alkmaar (J) | - | Borussia Dortmund II | 1:2 (0:2) | ||
| 27.03.2022 | 14:00 | Djurgårdens IF | - | FC Honka | 0:2 |
