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| 22.03.2021 | 12:00 | KAA Gent | - | RSC Anderlecht | 0:0 | |
| 24.03.2021 | 12:00 | AFC Ajax | - | FC Utrecht | 2:1 (2:1) | |
| 13:00 | RKC Waalwijk | - | Vitesse | 3:1 (0:1) | ||
| 25.03.2021 | Eintracht Frankfurt | - | SV Wehen Wiesbaden | n.gesp. | ||
| 12:00 | Willem II | - | Feyenoord | 1:0 (0:0) | ||
| 13:00 | FC Nordsjælland | - | Brøndby IF | 1:5 | ||
| 13:00 | PEC Zwolle | - | FC Twente | 0:5 (0:2) | ||
| 13:00 | ADO Den Haag | - | AZ Alkmaar | 0:2 (0:0) | ||
| 14:00 | 1. FSV Mainz 05 | - | 1. FC Nürnberg | 2:2 | ||
| 14:00 | Chemnitzer FC | - | Hallescher FC | 1:0 | ||
| 14:00 | FC Carl Zeiss Jena | - | Dynamo Dresden | 0:5 | ||
| 14:00 | FC Wil 1900 | - | FC Vaduz | 1:1 | ||
| 15:00 | 1. FC Union Berlin | - | Eintracht Braunschweig | 1:2 (0:2) | ||
| 15:00 | VfB Stuttgart | - | Würzburger Kickers | 3:0 | ||
| 26.03.2021 | 12:00 | RSC Anderlecht | - | KV Kortrijk | 1:2 (1:1) | |
| 13:00 | Fortuna Düsseldorf | - | SC Verl | 2:2 (1:1) | ||
| 14:00 | FC Augsburg | - | 1. FC Heidenheim 1846 | 3:1 (2:1) | ||
| 14:00 | Malmö FF | - | IFK Göteborg | 2:1 (0:1) |
