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| 25.09.2021 | 18:00 | Andrézieux-Bouthéon FC | - | Canet Roussillon | 1:1 (0:1) | |
| 18:00 | Bergerac Périgord FC | - | Bourges Foot 18 | 2:1 (1:1) | ||
| 18:00 | Montpellier HSC (CFA) | - | Trélissac FC | 1:2 (0:2) | ||
| 18:00 | Le Puy Foot 43 | - | Stade Montois | 4:0 (2:0) | ||
| 18:00 | Angers SCO II | - | AS Béziers | 2:0 (0:0) | ||
| 18:00 | US Colomiers | - | FC Nantes (CFA) | 0:2 (0:1) | ||
| 18:00 | Vendée Les Herbiers | - | Moulins Yzeure Foot | 0:2 (0:1) | ||
| 20:00 | FC Chamalières | - | Angoulême CFC | 1:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Angoulême CFC | 8 | 6 | 1 | 1 | 14:6 | 8 | 19 |
| 2 |
|
Bergerac Périgord FC | 8 | 5 | 1 | 2 | 12:6 | 6 | 16 |
| 3 |
|
Moulins Yzeure Foot | 8 | 4 | 4 | 0 | 7:1 | 6 | 16 |
| 4 |
|
FC Nantes (CFA) | 8 | 4 | 3 | 1 | 12:8 | 4 | 15 |
| 5 |
|
Le Puy Foot 43 | 8 | 4 | 2 | 2 | 10:4 | 6 | 14 |
| 6 |
|
AS Béziers | 8 | 4 | 2 | 2 | 8:7 | 1 | 14 |
| 7 |
|
Andrézieux-Bouthéon FC | 8 | 4 | 1 | 3 | 11:8 | 3 | 13 |
| 8 |
|
US Colomiers | 8 | 3 | 2 | 3 | 7:7 | 0 | 11 |
| 9 |
|
Trélissac FC | 8 | 3 | 1 | 4 | 6:9 | -3 | 10 |
| 10 |
|
Vendée Les Herbiers | 8 | 2 | 3 | 3 | 10:12 | -2 | 9 |
| 11 |
|
Angers SCO II | 8 | 2 | 3 | 3 | 6:9 | -3 | 9 |
| 12 |
|
Bourges Foot 18 | 8 | 2 | 2 | 4 | 6:7 | -1 | 8 |
| 13 |
|
FC Chamalières | 8 | 1 | 2 | 5 | 7:14 | -7 | 5 |
| 14 |
|
Canet Roussillon | 8 | 4 | 3 | 1 | 10:7 | 3 | 4 |
| 15 |
|
Montpellier HSC (CFA) | 8 | 0 | 2 | 6 | 6:12 | -6 | 2 |
| 16 |
|
Stade Montois | 8 | 0 | 0 | 8 | 7:22 | -15 | 0 |
| Aufstieg | |
| Abstieg |
