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| 20.12.2005 | 20:00 | EA Guingamp | - | SM Caen | 2:0 (1:0) | |
| 20:00 | OGC Nice | - | CS Sedan | 2:0 (1:0) | ||
| 21:00 | Girondins Bordeaux | - | FC Nantes | 3:1 (2:0) | ||
| 21.12.2005 | 17:00 | Toulouse FC | - | Paris Saint-Germain | 2:0 (0:0) | |
| 20:00 | AS Monaco | - | Lille OSC | 1:0 (0:0) | ||
| 20:00 | AS Nancy Lorraine | - | FC Lorient | 1:0 (1:0) | ||
| 20:00 | AJ Auxerre | - | Le Mans UC 72 | 1:4 (0:0, 1:1, 1:1) i.E. | ||
| 20:00 | Montpellier HSC | - | AC Ajaccio | 0:1 (0:0) |
