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| 05.03.2021 | 21:00 | AS Beauvais | - | US Boulogne | 0:2 (0:1) | |
| 21:00 | Aubagne FC | - | Toulouse FC | 0:2 (0:1) | ||
| 06.03.2021 | 14:15 | Red Star FC | - | RC Lens | 3:2 (1:1) | |
| 14:15 | GFA Rumilly Vallières | - | FC Annecy | 6:5 (1:0, 1:1) i.E. | ||
| 14:15 | FC Saint-Louis Neuweg | - | CS Sedan | 0:2 (0:0) | ||
| 14:15 | Olympique Alès | - | Montpellier HSC | 1:2 (1:1) | ||
| 16:30 | Valenciennes FC | - | FC Metz | 0:4 (0:2) | ||
| 16:30 | Le Puy Foot 43 | - | FC Lorient | 1:0 (0:0) | ||
| 16:30 | Olympique Saumur | - | US Montagnarde | 4:3 (1:1, 3:3) i.E. | ||
| 18:45 | Olympique Lyonnais | - | FC Sochaux | 5:2 (3:1) | ||
| 21:10 | Stade Brestois 29 | - | Paris Saint-Germain | 0:3 (0:2) | ||
| 07.03.2021 | 18:30 | Gazélec FC Ajaccio | - | Lille OSC | 1:3 (0:1) | |
| 18:30 | Angers SCO | - | Club Franciscain | 5:0 (2:0) | ||
| 18:30 | SO Romorantin | - | Châteaubriant Voltigeurs | 1:3 (0:2) | ||
| 21:00 | Canet Roussillon | - | Olympique Marseille | 2:1 (1:1) | ||
| 08.03.2021 | 21:00 | OGC Nice | - | AS Monaco | 0:2 (0:1) |
