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| 11.02.2000 | 19:30 | AS Saint-Étienne | - | FC Lorient | 3:4 (0:0, 0:0, 0:0) i.E. | |
| 20:00 | Amiens SC | - | Stade Lavallois | 5:3 (0:0, 0:0, 1:1) i.E. | ||
| 20:00 | Racing Besançon | - | RC Strasbourg | 2:4 (1:1, 1:1, 2:2) i.E. | ||
| 20:00 | Chamois Niortais | - | AS Cannes | 0:3 (0:2) | ||
| 12.02.2000 | 14:30 | FC Montceau | - | FC Nantes | 0:6 (0:2) | |
| 17:00 | Olympique Lyonnais | - | ATAC Troyes | 1:0 (1:0) | ||
| 18:00 | Calais RUFC | - | Langon FC | 3:0 (1:0) | ||
| 18:30 | Vendée Les Herbiers | - | Stade Rennais | 0:4 (0:2) | ||
| 19:30 | Thouars Foot 79 | - | AS Monaco | 1:2 (0:0) | ||
| 19:30 | GSI Pontivy | - | ASOA Valence | 2:1 (2:0) | ||
| 20:00 | AS Porto Vecchio | - | Girondins Bordeaux | 1:4 (1:1) | ||
| 20:00 | Olympique Marseille | - | FC Gueugnon | 3:4 (0:2) | ||
| 20:00 | Olympique Saint-Quentin | - | FC Metz | 1:3 (1:0, 1:1) n.V. | ||
| 20:00 | Nîmes Olympique | - | Toulouse FC | 1:0 (1:0) | ||
| 20:00 | AS Baume-les-Dames | - | Paris Saint-Germain | 0:2 (0:1) | ||
| 20:00 | AS Red Star 93 | - | Havre AC | 1:0 (1:0) |
