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| H | AEK Larnaca | - | Partizan | 2:1 (1:1) | ||
| R | Partizan | - | AEK Larnaca | 2:2 (1:0) | ||
| H: 04.08.2022 18:00 | R: 11.08.2022 21:00 | Sieger: AEK Larnaca | ||||
| H | Malmö FF | - | F91 Dudelange | 3:0 (0:0) | ||
| R | F91 Dudelange | - | Malmö FF | 2:2 (0:0) | ||
| H: 04.08.2022 19:00 | R: 11.08.2022 20:00 | Sieger: Malmö FF | ||||
| H | Fenerbahçe | - | 1. FC Slovácko | 3:0 (2:0) | ||
| R | 1. FC Slovácko | - | Fenerbahçe | 1:1 (0:0) | ||
| H: 04.08.2022 19:00 | R: 11.08.2022 19:00 | Sieger: Fenerbahçe | ||||
| H | NK Maribor | - | HJK Helsinki | 0:2 (0:0) | ||
| R | HJK Helsinki | - | NK Maribor | 1:0 (0:0) | ||
| H: 04.08.2022 20:15 | R: 11.08.2022 18:00 | Sieger: HJK Helsinki | ||||
| H | Linfield FC | - | FC Zürich | 0:2 (0:1) | ||
| R | FC Zürich | - | Linfield FC | 3:0 (2:0) | ||
| H: 04.08.2022 20:45 | R: 11.08.2022 19:00 | Sieger: FC Zürich | ||||
| H | Shamrock Rovers | - | KF Shkupi | 3:1 (2:0) | ||
| R | KF Shkupi | - | Shamrock Rovers | 1:2 (0:0) | ||
| H: 04.08.2022 21:00 | R: 09.08.2022 21:00 | Sieger: Shamrock Rovers | ||||
| H | Olympiakos Piraeus | - | Slovan Bratislava | 1:1 (0:0) | ||
| R | Slovan Bratislava | - | Olympiakos Piraeus | 3:4 (0:0, 1:1, 2:2) i.E. | ||
| H: 04.08.2022 21:00 | R: 11.08.2022 20:30 | Sieger: Olympiakos Piraeus | ||||
