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| H | Neftçi PFK | - | HJK Helsinki | 2:2 (0:0) | ||
| R | HJK Helsinki | - | Neftçi PFK | 3:0 (0:0) | ||
| H: 03.08.2021 19:00 | R: 12.08.2021 18:00 | Sieger: HJK Helsinki | ||||
| H | FK Kairat | - | FC Alashkert | 0:0 (0:0) | ||
| R | FC Alashkert | - | FK Kairat | 3:2 (1:1, 2:2) n.V. | ||
| H: 05.08.2021 16:00 | R: 12.08.2021 17:00 | Sieger: FC Alashkert | ||||
| H | FK Jablonec | - | Celtic FC | 2:4 (1:2) | ||
| R | Celtic FC | - | FK Jablonec | 3:0 (1:0) | ||
| H: 05.08.2021 17:45 | R: 12.08.2021 20:45 | Sieger: Celtic FC | ||||
| H | Omonia Nikosia | - | FC Flora | 1:0 (1:0) | ||
| R | FC Flora | - | Omonia Nikosia | 4:5 (0:1, 2:1, 2:1) i.E. | ||
| H: 05.08.2021 18:00 | R: 10.08.2021 18:00 | Sieger: Omonia Nikosia | ||||
| H | Lincoln Red Imps | - | Slovan Bratislava | 1:3 (0:1) | ||
| R | Slovan Bratislava | - | Lincoln Red Imps | 1:1 (1:0) | ||
| H: 05.08.2021 18:00 | R: 10.08.2021 20:30 | Sieger: Slovan Bratislava | ||||
| H | NŠ Mura | - | FK Žalgiris | 0:0 (0:0) | ||
| R | FK Žalgiris | - | NŠ Mura | 0:1 (0:1) | ||
| H: 05.08.2021 20:00 | R: 12.08.2021 19:00 | Sieger: NŠ Mura | ||||
| H | Galatasaray | - | St. Johnstone FC | 1:1 (0:0) | ||
| R | St. Johnstone FC | - | Galatasaray | 2:4 (1:1) | ||
| H: 05.08.2021 20:00 | R: 12.08.2021 20:00 | Sieger: Galatasaray | ||||
| H | Rapid Wien | - | Anorthosis Famagusta | 3:0 (1:0) | ||
| R | Anorthosis Famagusta | - | Rapid Wien | 2:1 (1:0) | ||
| H: 05.08.2021 20:30 | R: 12.08.2021 19:00 | Sieger: Rapid Wien | ||||
