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| H | Dinamo Kiev | - | Club Brugge KV | 1:1 (0:0) | ||
| R | Club Brugge KV | - | Dinamo Kiev | 0:1 (0:0) | ||
| H: 18.02.2021 16:00 | R: 25.02.2021 21:00 | Sieger: Dinamo Kiev | ||||
| H | Wolfsberger AC | - | Tottenham Hotspur | 1:4 (0:3) | ||
| R | Tottenham Hotspur | - | Wolfsberger AC | 4:0 (1:0) | ||
| H: 18.02.2021 18:55 | R: 24.02.2021 18:00 | Sieger: Tottenham Hotspur | ||||
| H | Real Sociedad | - | Manchester United | 0:4 (0:1) | ||
| R | Manchester United | - | Real Sociedad | 0:0 (0:0) | ||
| H: 18.02.2021 18:55 | R: 25.02.2021 21:00 | Sieger: Manchester United | ||||
| H | Crvena Zvezda | - | AC Milan | 2:2 (0:1) | ||
| R | AC Milan | - | Crvena Zvezda | 1:1 (1:1) | ||
| H: 18.02.2021 18:55 | R: 25.02.2021 21:00 | Sieger: AC Milan | ||||
| H | Slavia Praha | - | Leicester City | 0:0 (0:0) | ||
| R | Leicester City | - | Slavia Praha | 0:2 (0:0) | ||
| H: 18.02.2021 18:55 | R: 25.02.2021 21:00 | Sieger: Slavia Praha | ||||
| H | Sporting Braga | - | AS Roma | 0:2 (0:1) | ||
| R | AS Roma | - | Sporting Braga | 3:1 (1:0) | ||
| H: 18.02.2021 18:55 | R: 25.02.2021 21:00 | Sieger: AS Roma | ||||
| H | FK Krasnodar | - | Dinamo Zagreb | 2:3 (1:1) | ||
| R | Dinamo Zagreb | - | FK Krasnodar | 1:0 (1:0) | ||
| H: 18.02.2021 18:55 | R: 25.02.2021 21:00 | Sieger: Dinamo Zagreb | ||||
| H | BSC Young Boys | - | Bayer Leverkusen | 4:3 (3:0) | ||
| R | Bayer Leverkusen | - | BSC Young Boys | 0:2 (0:0) | ||
| H: 18.02.2021 18:55 | R: 25.02.2021 21:00 | Sieger: BSC Young Boys | ||||
| H | Olympiakos Piraeus | - | PSV Eindhoven | 4:2 (3:2) | ||
| R | PSV Eindhoven | - | Olympiakos Piraeus | 2:1 (2:0) | ||
| H: 18.02.2021 18:55 | R: 25.02.2021 21:00 | Sieger: Olympiakos Piraeus | ||||
| H | SL Benfica | - | Arsenal FC | 1:1 (0:0) | ||
| R | Arsenal FC | - | SL Benfica | 3:2 (1:1) | ||
| H: 18.02.2021 21:00 | R: 25.02.2021 18:55 | Sieger: Arsenal FC | ||||
| H | Royal Antwerp FC | - | Rangers FC | 3:4 (2:1) | ||
| R | Rangers FC | - | Royal Antwerp FC | 5:2 (1:1) | ||
| H: 18.02.2021 21:00 | R: 25.02.2021 18:55 | Sieger: Rangers FC | ||||
| H | RB Salzburg | - | Villarreal CF | 0:2 (0:1) | ||
| R | Villarreal CF | - | RB Salzburg | 2:1 (1:1) | ||
| H: 18.02.2021 21:00 | R: 25.02.2021 18:55 | Sieger: Villarreal CF | ||||
| H | Molde FK | - | 1899 Hoffenheim | 3:3 (1:3) | ||
| R | 1899 Hoffenheim | - | Molde FK | 0:2 (0:1) | ||
| H: 18.02.2021 21:00 | R: 25.02.2021 18:55 | Sieger: Molde FK | ||||
| H | Granada CF | - | SSC Napoli | 2:0 (2:0) | ||
| R | SSC Napoli | - | Granada CF | 2:1 (1:1) | ||
| H: 18.02.2021 21:00 | R: 25.02.2021 18:55 | Sieger: Granada CF | ||||
| H | Maccabi Tel Aviv | - | Shakhtar Donetsk | 0:2 (0:1) | ||
| R | Shakhtar Donetsk | - | Maccabi Tel Aviv | 1:0 (0:0) | ||
| H: 18.02.2021 21:00 | R: 25.02.2021 18:55 | Sieger: Shakhtar Donetsk | ||||
| H | Lille OSC | - | AFC Ajax | 1:2 (0:0) | ||
| R | AFC Ajax | - | Lille OSC | 2:1 (1:0) | ||
| H: 18.02.2021 21:00 | R: 25.02.2021 18:55 | Sieger: AFC Ajax | ||||
