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| H | Zenit St. Petersburg | - | Torino FC | 2:0 (1:0) | ||
| R | Torino FC | - | Zenit St. Petersburg | 1:0 (0:0) | ||
| H: 12.03.2015 18:00 | R: 19.03.2015 21:05 | Sieger: Zenit St. Petersburg | ||||
| H | Dnipro Dnipropetrovsk | - | AFC Ajax | 1:0 (1:0) | ||
| R | AFC Ajax | - | Dnipro Dnipropetrovsk | 2:1 (0:0, 1:0) n.V. | ||
| H: 12.03.2015 19:00 | R: 19.03.2015 21:05 | Sieger: Dnipro Dnipropetrovsk | ||||
| H | VfL Wolfsburg | - | Inter | 3:1 (1:1) | ||
| R | Inter | - | VfL Wolfsburg | 1:2 (0:1) | ||
| H: 12.03.2015 19:00 | R: 19.03.2015 21:05 | Sieger: VfL Wolfsburg | ||||
| H | Club Brugge KV | - | Beşiktaş | 2:1 (0:0) | ||
| R | Beşiktaş | - | Club Brugge KV | 1:3 (0:0) | ||
| H: 12.03.2015 19:00 | R: 19.03.2015 21:05 | Sieger: Club Brugge KV | ||||
| H | Everton FC | - | Dinamo Kiev | 2:1 (1:1) | ||
| R | Dinamo Kiev | - | Everton FC | 5:2 (3:1) | ||
| H: 12.03.2015 21:05 | R: 19.03.2015 19:00 | Sieger: Dinamo Kiev | ||||
| H | Villarreal CF | - | Sevilla FC | 1:3 (0:2) | ||
| R | Sevilla FC | - | Villarreal CF | 2:1 (0:0) | ||
| H: 12.03.2015 21:05 | R: 19.03.2015 21:05 | Sieger: Sevilla FC | ||||
| H | SSC Napoli | - | Dinamo Moskva | 3:1 (2:1) | ||
| R | Dinamo Moskva | - | SSC Napoli | 0:0 (0:0) | ||
| H: 12.03.2015 21:05 | R: 19.03.2015 18:00 | Sieger: SSC Napoli | ||||
| H | ACF Fiorentina | - | AS Roma | 1:1 (1:0) | ||
| R | AS Roma | - | ACF Fiorentina | 0:3 (0:3) | ||
| H: 12.03.2015 21:05 | R: 19.03.2015 19:00 | Sieger: ACF Fiorentina | ||||
