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| 07.01.2022 | 21:00 | SD Amorebieta | - | CD Tenerife | 1:1 (1:1) | |
| 08.01.2022 | 16:00 | FC Cartagena | - | SD Huesca | 0:3 (0:1) | |
| 16:00 | UD Ibiza | - | AD Alcorcón | 6:2 (2:2) | ||
| 18:15 | Real Valladolid | - | Burgos CF | 1:0 (0:0) | ||
| 21:00 | CD Leganés | - | Real Sociedad B | 1:1 (0:0) | ||
| 09.01.2022 | 14:00 | Girona FC | - | CF Fuenlabrada | 2:1 (2:0) | |
| 16:00 | CD Lugo | - | CD Mirandés | 2:1 (1:0) | ||
| 18:15 | Málaga CF | - | Sporting Gijón | 2:2 (1:2) | ||
| 20:30 | SD Ponferradina | - | Real Zaragoza | 0:0 (0:0) | ||
| 21:30 | UD Las Palmas | - | UD Almería | 1:1 (1:0) | ||
| 10.01.2022 | 21:00 | Real Oviedo | - | SD Eibar | 1:1 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 23 | 14 | 4 | 5 | 39:17 | 22 | 46 |
| 2 |
|
SD Eibar | 23 | 12 | 7 | 4 | 35:27 | 8 | 43 |
| 3 |
|
Real Valladolid | 23 | 13 | 4 | 6 | 35:24 | 11 | 43 |
| 4 |
|
CD Tenerife | 23 | 11 | 6 | 6 | 29:18 | 11 | 39 |
| 5 |
|
SD Ponferradina | 23 | 10 | 8 | 5 | 28:20 | 8 | 38 |
| 6 |
|
Girona FC | 23 | 11 | 4 | 8 | 32:26 | 6 | 37 |
| 7 |
|
UD Las Palmas | 23 | 9 | 8 | 6 | 30:27 | 3 | 35 |
| 8 |
|
FC Cartagena | 23 | 10 | 3 | 10 | 28:31 | -3 | 33 |
| 9 |
|
Real Oviedo | 23 | 7 | 12 | 4 | 26:20 | 6 | 33 |
| 10 |
|
UD Ibiza | 23 | 7 | 10 | 6 | 27:26 | 1 | 31 |
| 11 |
|
Málaga CF | 23 | 8 | 7 | 8 | 23:30 | -7 | 31 |
| 12 |
|
CD Lugo | 23 | 6 | 12 | 5 | 29:27 | 2 | 30 |
| 13 |
|
SD Huesca | 23 | 7 | 9 | 7 | 25:21 | 4 | 30 |
| 14 |
|
Sporting Gijón | 23 | 7 | 8 | 8 | 24:27 | -3 | 29 |
| 15 |
|
Burgos CF | 23 | 8 | 5 | 10 | 23:24 | -1 | 29 |
| 16 |
|
Real Zaragoza | 23 | 5 | 12 | 6 | 17:23 | -6 | 27 |
| 17 |
|
CD Leganés | 23 | 6 | 8 | 9 | 25:26 | -1 | 26 |
| 18 |
|
CD Mirandés | 23 | 7 | 5 | 11 | 31:36 | -5 | 26 |
| 19 |
|
SD Amorebieta | 23 | 3 | 12 | 8 | 27:34 | -7 | 21 |
| 20 |
|
CF Fuenlabrada | 23 | 3 | 11 | 9 | 17:26 | -9 | 20 |
| 21 |
|
Real Sociedad B | 23 | 4 | 6 | 13 | 19:31 | -12 | 18 |
| 22 |
|
AD Alcorcón | 23 | 2 | 5 | 16 | 18:46 | -28 | 11 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
