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| H | Mineros SC | - | Barcelona | 1:1 (0:1) | ||
| R | Barcelona | - | Mineros SC | 2:0 (2:0) | ||
| H: 24.04.2019 19:30 | R: 17.05.2019 02:30 | Sieger: Barcelona | ||||
| H | América de Quito | - | Liga de Portoviejo | 4:0 (3:0) | ||
| R | Liga de Portoviejo | - | América de Quito | 2:2 (1:1) | ||
| H: 24.04.2019 22:00 | R: 29.05.2019 19:00 | Sieger: América de Quito | ||||
| H | FC Insutec | - | Delfín SC | 1:2 (1:1) | ||
| R | Delfín SC | - | FC Insutec | 0:0 (0:0) | ||
| H: 25.04.2019 00:45 | R: 23.05.2019 02:30 | Sieger: Delfín SC | ||||
| H | Aucas | - | Toreros FC | 2:0 (1:0) | ||
| R | Toreros FC | - | Aucas | 0:2 (0:1) | ||
| H: 25.04.2019 03:00 | R: 30.05.2019 02:00 | Sieger: Aucas | ||||
| H | Atlético Porteño | - | Macará | 1:2 (0:1) | ||
| R | Macará | - | Atlético Porteño | 3:1 (1:1) | ||
| H: 25.04.2019 22:30 | R: 16.05.2019 00:15 | Sieger: Macará | ||||
| H | Guayaquil City | - | Clan Juvenil | 6:1 (5:1) | ||
| R | Clan Juvenil | - | Guayaquil City | 2:1 (0:0) | ||
| H: 26.04.2019 01:00 | R: 16.05.2019 22:00 | Sieger: Guayaquil City | ||||
| H | Anaconda FC | - | El Nacional | 1:1 (0:0) | ||
| R | El Nacional | - | Anaconda FC | 4:0 (1:0) | ||
| H: 30.04.2019 22:00 | R: 28.05.2019 19:30 | Sieger: El Nacional | ||||
| H | Independiente del Valle | - | Orense SC | 1:1 (1:1) | ||
| R | Orense SC | - | Independiente del Valle | 0:0 (0:0) | ||
| H: 01.05.2019 01:00 | R: 14.05.2019 22:00 | Sieger: Orense SC | ||||
| H | Emelec | - | Puerto Quito | 2:0 (0:0) | ||
| R | Atlético Santo Domingo | - | Emelec | 0:2 (0:1) | ||
| H: 02.05.2019 00:15 | R: 15.05.2019 22:00 | Sieger: Emelec | ||||
| H | LDU Quito | - | Gloria | 5:0 (1:0) | ||
| R | Gloria | - | LDU Quito | 0:0 (0:0) | ||
| H: 02.05.2019 02:30 | R: 16.05.2019 03:00 | Sieger: LDU Quito | ||||
| H | Santa Rita | - | Fuerza Amarilla | 1:0 (0:0) | ||
| R | Fuerza Amarilla | - | Santa Rita | 1:3 (1:2) | ||
| H: 02.05.2019 23:00 | R: 29.05.2019 22:00 | Sieger: Santa Rita | ||||
| H | Gualaceo SC | - | Deportivo Cuenca | 0:1 (0:0) | ||
| R | Deportivo Cuenca | - | Gualaceo SC | 1:0 (1:0) | ||
| H: 03.05.2019 02:30 | R: 15.05.2019 03:15 | Sieger: Deportivo Cuenca | ||||
| H | Independiente Juniors | - | Universidad Catolica | 2:0 (1:0) | ||
| R | Universidad Catolica | - | Independiente Juniors | 1:1 (1:1) | ||
| H: 07.05.2019 23:00 | R: 19.06.2019 23:00 | Sieger: Independiente Juniors | ||||
| H | Olmedo | - | Alianza de Guano | 1:0 (0:0) | ||
| R | Alianza de Guano | - | Olmedo | 3:1 (1:0) | ||
| H: 08.05.2019 02:00 | R: 28.05.2019 22:30 | Sieger: Alianza de Guano | ||||
| H | Manta | - | Mushuc Runa | 0:2 (0:1) | ||
| R | Mushuc Runa | - | Manta | 4:0 (1:0) | ||
| H: 08.05.2019 22:00 | R: 22.05.2019 19:00 | Sieger: Mushuc Runa | ||||
| H | Técnico Universitario | - | Liga de Loja | 3:0 (1:0) | ||
| R | Liga de Loja | - | Técnico Universitario | 1:2 (0:2) | ||
| H: 10.05.2019 03:00 | R: 31.05.2019 02:30 | Sieger: Técnico Universitario | ||||
