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| H | AE Paphos | - | Olympiakos Nikosia | 0:0 (0:0) | ||
| R | Olympiakos Nikosia | - | AE Paphos | 3:1 (1:1) | ||
| H: 12.01.2011 15:00 | R: 26.01.2011 17:00 | Sieger: Olympiakos Nikosia | ||||
| H | AEL Limassol | - | Aris Limassol | 0:1 (0:1) | ||
| R | Aris Limassol | - | AEL Limassol | 0:0 (0:0) | ||
| H: 12.01.2011 15:00 | R: 26.01.2011 16:00 | Sieger: Aris Limassol | ||||
| H | Doxa Katokopias | - | AEK Larnaca | 0:1 (0:1) | ||
| R | AEK Larnaca | - | Doxa Katokopias | 4:1 (1:1) | ||
| H: 12.01.2011 15:00 | R: 19.01.2011 15:00 | Sieger: AEK Larnaca | ||||
| H | Ermis Aradippou | - | Ethnikos Achna | 0:1 (0:0) | ||
| R | Ethnikos Achna | - | Ermis Aradippou | 1:1 (0:1) | ||
| H: 12.01.2011 15:00 | R: 19.01.2011 17:00 | Sieger: Ethnikos Achna | ||||
| H | APOEL Nikosia | - | Apollon Limassol | 1:1 (0:1) | ||
| R | Apollon Limassol | - | APOEL Nikosia | 2:0 (1:0) | ||
| H: 12.01.2011 17:00 | R: 19.01.2011 17:00 | Sieger: Apollon Limassol | ||||
| H | Anorthosis Famagusta | - | APEP Pitsilias | 2:0 (1:0) | ||
| R | APEP Pitsilias | - | Anorthosis Famagusta | 0:1 (0:1) | ||
| H: 12.01.2011 17:00 | R: 02.02.2011 16:00 | Sieger: Anorthosis Famagusta | ||||
| H | Omonia Nikosia | - | Atromitos Yeroskipou | 6:0 (1:0) | ||
| R | Atromitos Yeroskipou | - | Omonia Nikosia | 2:2 (1:2) | ||
| H: 19.01.2011 15:00 | R: 26.01.2011 15:00 | Sieger: Omonia Nikosia | ||||
| H | Enosis Neon Paralimni | - | Alki Larnaca | 0:1 (0:1) | ||
| R | Alki Larnaca | - | Enosis Neon Paralimni | 4:3 (3:1) | ||
| H: 26.01.2011 17:00 | R: 16.02.2011 17:00 | Sieger: Alki Larnaca | ||||
