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| H | Tigre | - | Deportivo Anzoátegui | 2:1 (0:1) | ||
| R | Deportivo Anzoátegui | - | Tigre | 0:3 (0:1) | ||
| H: 23.01.2013 00:15 | R: 29.01.2013 23:15 | Sieger: Tigre | ||||
| H | Club León | - | Deportes Iquique | 1:1 (0:1) | ||
| R | Deportes Iquique | - | Club León | 4:2 (0:0, 1:1, 1:1) i.E. | ||
| H: 23.01.2013 02:45 | R: 30.01.2013 02:00 | Sieger: Deportes Iquique | ||||
| H | LDU Quito | - | Grêmio Porto Alegre | 1:0 (0:0) | ||
| R | Grêmio Porto Alegre | - | LDU Quito | 5:4 (0:0, 1:0, 1:0) i.E. | ||
| H: 24.01.2013 01:00 | R: 31.01.2013 01:00 | Sieger: Grêmio Porto Alegre | ||||
| H | São Paulo FC | - | Bolívar | 5:0 (3:0) | ||
| R | Bolívar | - | São Paulo FC | 4:3 (1:3) | ||
| H: 24.01.2013 01:00 | R: 31.01.2013 01:00 | Sieger: São Paulo FC | ||||
| H | Defensor Sporting | - | Club Olimpia | 0:0 (0:0) | ||
| R | Club Olimpia | - | Defensor Sporting | 2:0 (1:0) | ||
| H: 24.01.2013 23:00 | R: 31.01.2013 23:15 | Sieger: Club Olimpia | ||||
| H | Deportes Tolima | - | Universidad Cesar Vallejo | 1:0 (0:0) | ||
| R | Universidad Cesar Vallejo | - | Deportes Tolima | 1:1 (1:0) | ||
| H: 25.01.2013 01:15 | R: 01.02.2013 01:45 | Sieger: Deportes Tolima | ||||
