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| H | FAS | - | Árabe Unido | 0:1 (0:0) | ||
| R | Árabe Unido | - | FAS | 3:1 (0:1) | ||
| H: 22.08.2018 04:00 | R: 29.08.2018 04:00 | Sieger: Árabe Unido | ||||
| H | CS Herediano | - | UD Universitario | 3:0 (1:0) | ||
| R | UD Universitario | - | CS Herediano | 1:2 (0:0) | ||
| H: 23.08.2018 04:00 | R: 30.08.2018 04:00 | Sieger: CS Herediano | ||||
| H | Tauro FC | - | CD Walter Ferretti | 3:1 (2:1) | ||
| R | CD Walter Ferretti | - | Tauro FC | 0:4 (0:2) | ||
| H: 24.08.2018 02:00 | R: 31.08.2018 02:00 | Sieger: Tauro FC | ||||
| H | Motagua | - | Portmore United | 3:2 (2:0) | ||
| R | Portmore United | - | Motagua | 0:2 (0:1) | ||
| H: 24.08.2018 04:00 | R: 31.08.2018 04:00 | Sieger: Motagua | ||||
