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| H | Columbus Crew | - | Real Salt Lake | 0:0 (0:0) | ||
| R | Real Salt Lake | - | Columbus Crew | 4:1 (2:0) | ||
| H: 23.02.2011 02:00 | R: 02.03.2011 04:00 | Sieger: Real Salt Lake | ||||
| H | Cruz Azul | - | Santos Laguna | 2:0 (0:0) | ||
| R | Santos Laguna | - | Cruz Azul | 1:3 (0:1) | ||
| H: 23.02.2011 04:00 | R: 02.03.2011 02:00 | Sieger: Cruz Azul | ||||
| H | Deportivo Toluca | - | CF Monterrey | 0:1 (0:0) | ||
| R | CF Monterrey | - | Deportivo Toluca | 1:0 (0:0) | ||
| H: 24.02.2011 02:00 | R: 03.03.2011 02:00 | Sieger: CF Monterrey | ||||
| H | Deportivo Saprissa | - | Olimpia | 1:0 (1:0) | ||
| R | Olimpia | - | Deportivo Saprissa | 1:2 (0:1) | ||
| H: 25.02.2011 02:00 | R: 04.03.2011 02:00 | Sieger: Deportivo Saprissa | ||||
