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| H | Real Salt Lake | - | Deportivo Saprissa | 2:0 (1:0) | ||
| R | Deportivo Saprissa | - | Real Salt Lake | 2:1 (0:0) | ||
| H: 16.03.2011 03:00 | R: 06.04.2011 04:00 | Sieger: Real Salt Lake | ||||
| H | CF Monterrey | - | Cruz Azul | 2:1 (1:0) | ||
| R | Cruz Azul | - | CF Monterrey | 1:1 (1:0) | ||
| H: 17.03.2011 03:00 | R: 07.04.2011 02:00 | Sieger: CF Monterrey | ||||
