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| H | América de Cali | - | Millonarios | 1:2 (0:1) | ||
| R | Millonarios | - | América de Cali | 0:0 (0:0) | ||
| H: 24.04.2021 22:30 | R: 02.05.2021 01:00 | Sieger: Millonarios | ||||
| H | Atlético Junior | - | Santa Fe | 3:1 (1:0) | ||
| R | Santa Fe | - | Atlético Junior | 0:0 (0:0) | ||
| H: 25.04.2021 22:30 | R: 02.05.2021 20:00 | Sieger: Atlético Junior | ||||
| H | Deportes Tolima | - | Deportivo Cali | 3:0 (1:0) | ||
| R | Deportivo Cali | - | Deportes Tolima | 2:0 (2:0) | ||
| H: 26.04.2021 00:40 | R: 04.06.2021 22:30 | Sieger: Deportes Tolima | ||||
| H | La Equidad | - | Atlético Nacional | 1:0 (0:0) | ||
| R | Atlético Nacional | - | La Equidad | 2:2 (0:0) | ||
| H: 26.04.2021 03:00 | R: 02.05.2021 22:30 | Sieger: La Equidad | ||||
