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| H | Atlético Junior | - | Unión Magdalena | 0:1 (0:1) | ||
| R | Unión Magdalena | - | Atlético Junior | 0:1 (0:0, 0:1, 3:5) i.E. | ||
| H: 25.08.2022 01:00 | R: 15.09.2022 01:00 | Sieger: Atlético Junior | ||||
| H | Independiente Medellín | - | Millonarios | 0:2 (0:2) | ||
| R | Millonarios | - | Independiente Medellín | 2:2 (0:2) | ||
| H: 25.08.2022 03:05 | R: 08.09.2022 03:00 | Sieger: Millonarios | ||||
