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| 13.01.2021 | 23:30 | Deportes Quindío | - | Alianza Petrolera | 2:0 (1:0) | |
| 14.01.2021 | 02:00 | Independiente Medellín | - | Atlético Junior | 2:1 (0:1) | |
| 23:30 | Deportivo Pasto | - | América de Cali | 3:1 (1:1, 1:1) i.E. | ||
| 21.01.2021 | 21:15 | Deportes Tolima | - | Atlético Nacional | 2:0 (0:0) |
