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| H | FC Sheriff | - | Viktoria Plzeň | 1:2 (1:1) | ||
| R | Viktoria Plzeň | - | FC Sheriff | 2:1 (1:0) | ||
| H: 02.08.2022 19:00 | R: 09.08.2022 19:00 | Sieger: Viktoria Plzeň | ||||
| H | PFC Ludogorets Razgrad | - | Dinamo Zagreb | 1:2 (1:2) | ||
| R | Dinamo Zagreb | - | PFC Ludogorets Razgrad | 4:2 (3:1) | ||
| H: 02.08.2022 19:45 | R: 09.08.2022 20:00 | Sieger: Dinamo Zagreb | ||||
| H | AS Monaco | - | PSV Eindhoven | 1:1 (0:1) | ||
| R | PSV Eindhoven | - | AS Monaco | 3:2 (1:0, 2:2) n.V. | ||
| H: 02.08.2022 20:00 | R: 09.08.2022 20:30 | Sieger: PSV Eindhoven | ||||
| H | Union Saint-Gilloise | - | Rangers FC | 2:0 (1:0) | ||
| R | Rangers FC | - | Union Saint-Gilloise | 3:0 (1:0) | ||
| H: 02.08.2022 20:45 | R: 09.08.2022 20:45 | Sieger: Rangers FC | ||||
| H | SL Benfica | - | FC Midtjylland | 4:1 (3:0) | ||
| R | FC Midtjylland | - | SL Benfica | 1:3 (0:1) | ||
| H: 02.08.2022 21:00 | R: 09.08.2022 19:45 | Sieger: SL Benfica | ||||
| H | Qarabağ FK | - | Ferencvárosi TC | 1:1 (1:1) | ||
| R | Ferencvárosi TC | - | Qarabağ FK | 1:3 (0:1) | ||
| H: 03.08.2022 18:00 | R: 09.08.2022 20:00 | Sieger: Qarabağ FK | ||||
| H | FK Bodø/Glimt | - | FK Žalgiris | 5:0 (2:0) | ||
| R | FK Žalgiris | - | FK Bodø/Glimt | 1:1 (1:0) | ||
| H: 03.08.2022 18:00 | R: 09.08.2022 18:00 | Sieger: FK Bodø/Glimt | ||||
| H | Maccabi Haifa | - | Apollon Limassol | 4:0 (1:0) | ||
| R | Apollon Limassol | - | Maccabi Haifa | 2:0 (2:0) | ||
| H: 03.08.2022 19:00 | R: 09.08.2022 19:00 | Sieger: Maccabi Haifa | ||||
| H | Dinamo Kiev | - | Sturm Graz | 1:0 (1:0) | ||
| R | Sturm Graz | - | Dinamo Kiev | 1:2 (1:0, 1:0) n.V. | ||
| H: 03.08.2022 20:00 | R: 09.08.2022 20:30 | Sieger: Dinamo Kiev | ||||
| H | Crvena Zvezda | - | Pyunik FC | 5:0 (3:0) | ||
| R | Pyunik FC | - | Crvena Zvezda | 0:2 (0:1) | ||
| H: 03.08.2022 20:45 | R: 09.08.2022 19:00 | Sieger: Crvena Zvezda | ||||
