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| H | Manchester City | - | Borussia Dortmund | 2:1 (1:0) | ||
| R | Borussia Dortmund | - | Manchester City | 1:2 (1:0) | ||
| H: 06.04.2021 21:00 | R: 14.04.2021 21:00 | Sieger: Manchester City | ||||
| H | Real Madrid | - | Liverpool FC | 3:1 (2:0) | ||
| R | Liverpool FC | - | Real Madrid | 0:0 (0:0) | ||
| H: 06.04.2021 21:00 | R: 14.04.2021 21:00 | Sieger: Real Madrid | ||||
| H | FC Porto | - | Chelsea FC | 0:2 (0:1) | ||
| R | Chelsea FC | - | FC Porto | 0:1 (0:0) | ||
| H: 07.04.2021 21:00 | R: 13.04.2021 21:00 | Sieger: Chelsea FC | ||||
| H | Bayern München | - | Paris Saint-Germain | 2:3 (1:2) | ||
| R | Paris Saint-Germain | - | Bayern München | 0:1 (0:1) | ||
| H: 07.04.2021 21:00 | R: 13.04.2021 21:00 | Sieger: Paris Saint-Germain | ||||
