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| H | Banjul Hawks | - | Horoya AC | n.gesp. | ||
| R | Horoya AC | - | Banjul Hawks | n.gesp. | ||
| H: 09.09.2022 | R: 16.09.2022 | Sieger: Banjul Hawks | ||||
| H | Volcan Club de Moroni | - | La Passe FC | 1:0 (1:0) | ||
| R | La Passe FC | - | Volcan Club de Moroni | n.gesp. | ||
| H: 10.09.2022 14:30 | R: 16.09.2022 14:00 | Sieger: Volcan Club de Moroni | ||||
| H | APR FC | - | US Monastir | 1:0 (1:0) | ||
| R | US Monastir | - | APR FC | 3:0 (2:0) | ||
| H: 10.09.2022 15:00 | R: 18.09.2022 16:00 | Sieger: US Monastir | ||||
| H | Zalan FC | - | Young Africans | 0:4 (0:0) | ||
| R | Young Africans | - | Zalan FC | 5:0 (0:0) | ||
| H: 10.09.2022 15:00 | R: 17.09.2022 18:00 | Sieger: Young Africans | ||||
| H | KMKM | - | Al Ahly Tripolis | 0:2 (0:1) | ||
| R | Al Ahly Tripolis | - | KMKM | 4:0 (2:0) | ||
| H: 10.09.2022 15:00 | R: 17.09.2022 20:00 | Sieger: Al Ahly Tripolis | ||||
| H | Cape Town City FC | - | AS Otôho | 2:0 (0:0) | ||
| R | AS Otôho | - | Cape Town City FC | 0:0 (0:0) | ||
| H: 10.09.2022 15:00 | R: 18.09.2022 16:30 | Sieger: Cape Town City FC | ||||
| H | Red Arrows | - | CD 1º de Agosto | 0:1 (0:1) | ||
| R | CD 1º de Agosto | - | Red Arrows | 1:1 (1:1) | ||
| H: 10.09.2022 15:00 | R: 18.09.2022 17:00 | Sieger: CD 1º de Agosto | ||||
| H | Big Bullets FC | - | Simba SC | 0:2 (0:1) | ||
| R | Simba SC | - | Big Bullets FC | 2:0 (1:0) | ||
| H: 10.09.2022 15:00 | R: 18.09.2022 15:00 | Sieger: Simba SC | ||||
| H | Matlama | - | Coton Sport Garoua | 0:3 (0:1) | ||
| R | Coton Sport Garoua | - | Matlama | 1:0 (0:0) | ||
| H: 10.09.2022 16:00 | R: 18.09.2022 19:00 | Sieger: Coton Sport Garoua | ||||
| H | AS Stade Mandji | - | Plateau United | 2:2 (2:2) | ||
| R | Plateau United | - | AS Stade Mandji | 1:0 (0:0) | ||
| H: 10.09.2022 16:30 | R: 18.09.2022 17:00 | Sieger: Plateau United | ||||
| H | Deportivo Mongomo | - | Djoliba AC | 2:0 (1:0) | ||
| R | Djoliba AC | - | Deportivo Mongomo | 5:0 (4:0) | ||
| H: 10.09.2022 17:00 | R: 19.09.2022 18:00 | Sieger: Djoliba AC | ||||
| H | ASN Nigelec | - | SOAR | 2:1 (1:0) | ||
| R | SOAR | - | ASN Nigelec | 0:0 (0:0) | ||
| H: 10.09.2022 17:30 | R: 16.09.2022 18:00 | Sieger: ASN Nigelec | ||||
| H | Bo Rangers | - | CR Bélouizdad | 0:0 (0:0) | ||
| R | CR Bélouizdad | - | Bo Rangers | 3:0 (1:0) | ||
| H: 10.09.2022 18:00 | R: 17.09.2022 20:30 | Sieger: CR Bélouizdad | ||||
| H | Olympic Real | - | Vipers SC | 0:3 (0:1) | ||
| R | Vipers SC | - | Olympic Real | 1:0 (1:0) | ||
| H: 10.09.2022 21:00 | R: 17.09.2022 15:00 | Sieger: Vipers SC | ||||
| H | St. George SC | - | Al Hilal Omdurman | 2:1 (2:0) | ||
| R | Al Hilal Omdurman | - | St. George SC | 1:0 (0:0) | ||
| H: 11.09.2022 15:00 | R: 18.09.2022 19:00 | Sieger: Al Hilal Omdurman | ||||
| H | Flambeau du Centre | - | Al Ittihad Tripolis | 1:0 (1:0) | ||
| R | Al Ittihad Tripolis | - | Flambeau du Centre | 2:1 (1:1) | ||
| H: 11.09.2022 15:00 | R: 18.09.2022 19:00 | Sieger: Flambeau du Centre | ||||
| H | Black Bulls | - | Petro Atlético | 0:3 (0:0) | ||
| R | Petro Atlético | - | Black Bulls | 2:1 (2:1) | ||
| H: 11.09.2022 15:00 | R: 17.09.2022 17:00 | Sieger: Petro Atlético | ||||
| H | CFFA | - | Royal Leopards | 2:3 (1:1) | ||
| R | Royal Leopards | - | CFFA | 2:1 (0:1) | ||
| H: 11.09.2022 15:00 | R: 17.09.2022 15:00 | Sieger: Royal Leopards | ||||
| H | AS Arta | - | Al Merrikh SC | 1:2 (1:0) | ||
| R | Al Merrikh SC | - | AS Arta | 0:0 (0:0) | ||
| H: 11.09.2022 16:00 | R: 17.09.2022 14:30 | Sieger: Al Merrikh SC | ||||
| H | Rivers United | - | Watanga FC | 3:0 (3:0) | ||
| R | Watanga FC | - | Rivers United | 1:0 (1:0) | ||
| H: 11.09.2022 17:00 | R: 18.09.2022 18:00 | Sieger: Rivers United | ||||
| H | Coton FC | - | ASEC Mimosas | 1:2 (1:1) | ||
| R | ASEC Mimosas | - | Coton FC | 2:0 (1:0) | ||
| H: 11.09.2022 18:00 | R: 18.09.2022 18:00 | Sieger: ASEC Mimosas | ||||
| H | ASKO Kara | - | FC Nouadhibou | 1:1 (0:0) | ||
| R | FC Nouadhibou | - | ASKO Kara | 0:1 (0:1) | ||
| H: 11.09.2022 18:00 | R: 17.09.2022 21:00 | Sieger: ASKO Kara | ||||
| H | Gaborone United | - | AS Vita Club | 1:0 (1:0) | ||
| R | AS Vita Club | - | Gaborone United | 3:1 (2:1) | ||
| H: 11.09.2022 18:00 | R: 18.09.2022 16:30 | Sieger: AS Vita Club | ||||
| H | Casa Sport | - | JS Kabylie | 1:0 (0:0) | ||
| R | JS Kabylie | - | Casa Sport | 3:0 (2:0) | ||
| H: 11.09.2022 19:00 | R: 18.09.2022 20:00 | Sieger: JS Kabylie | ||||
| H | RC Kadiogo | - | Asante Kotoko | 0:1 (0:0) | ||
| R | Asante Kotoko | - | RC Kadiogo | 1:3 (0:1, 0:1) i.E. | ||
| H: 12.09.2022 19:00 | R: 18.09.2022 17:00 | Sieger: RC Kadiogo | ||||
| H | Tout-puissant Elect Sports | - | Zamalek | 0:2 (0:0) | ||
| R | Zamalek | - | Tout-puissant Elect Sports | 2:0 (0:0) | ||
| H: 18.09.2022 17:00 | R: 25.09.2022 20:00 | Sieger: Zamalek | ||||
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# La Passe kam eine Runde weiter, da der Gegner nicht zum Rückspiel antrat. |
