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| H | Coin Nord Mitsamiouli | - | Clube Ferroviário Maputo | 3:5 | ||
| R | Clube Ferroviário Maputo | - | Coin Nord Mitsamiouli | 4:1 | ||
| H: 12.02.2010 | R: 27.02.2010 | Sieger: Clube Ferroviário Maputo | ||||
| H | APR FC | - | CRD Libolo | 2:2 | ||
| R | CRD Libolo | - | APR FC | 0:1 | ||
| H: 13.02.2010 | R: 27.02.2010 | Sieger: APR FC | ||||
| H | ASC Linguère | - | Asante Kotoko | 2:0 | ||
| R | Asante Kotoko | - | ASC Linguère | 2:4 i.E. | ||
| H: 13.02.2010 | R: 28.02.2010 | Sieger: ASC Linguère | ||||
| H | Sofapaka FC | - | Ismaily | 0:0 | ||
| R | Ismaily | - | Sofapaka FC | 2:0 | ||
| H: 13.02.2010 | R: 27.02.2010 | Sieger: Ismaily | ||||
| H | US Stade Tamponnaise | - | Ajesaia | 2:1 | ||
| R | Ajesaia | - | US Stade Tamponnaise | 1:3 | ||
| H: 13.02.2010 | R: 28.02.2010 | Sieger: US Stade Tamponnaise | ||||
| H | Armed Forces | - | JS Kabylie | 1:2 | ||
| R | JS Kabylie | - | Armed Forces | 3:0 | ||
| H: 13.02.2010 | R: 27.02.2010 | Sieger: JS Kabylie | ||||
| H | East End Lions | - | Espérance de Tunis | 2:2 | ||
| R | Espérance de Tunis | - | East End Lions | 3:2 | ||
| H: 13.02.2010 | R: 26.02.2010 | Sieger: Espérance de Tunis | ||||
| H | Gaborone United | - | Orlando Pirates | 0:0 | ||
| R | Orlando Pirates | - | Gaborone United | 2:2 | ||
| H: 13.02.2010 | R: 28.02.2010 | Sieger: Gaborone United | ||||
| H | Young Africans | - | FC St. Eloi Lupopo | 2:3 | ||
| R | FC St. Eloi Lupopo | - | Young Africans | 1:0 | ||
| H: 13.02.2010 | R: 27.02.2010 | Sieger: FC St. Eloi Lupopo | ||||
| H | CF Os Balantas Mansoa | - | Difaâ d'el Jadida | 0:0 | ||
| R | Difaâ d'el Jadida | - | CF Os Balantas Mansoa | 3:0 | ||
| H: 13.02.2010 | R: 27.02.2010 | Sieger: Difaâ d'el Jadida | ||||
| H | Vital'O | - | Tiko United FC | 2:2 | ||
| R | Tiko United FC | - | Vital'O | 5:3 i.E. | ||
| H: 13.02.2010 | R: 27.02.2010 | Sieger: Tiko United FC | ||||
| H | Djoliba AC | - | Al Ahly Benghazi | 1:0 | ||
| R | Al Ahly Benghazi | - | Djoliba AC | 0:0 | ||
| H: 14.02.2010 | R: 28.02.2010 | Sieger: Djoliba AC | ||||
| H | Fello Star | - | Raja Casablanca | 1:3 | ||
| R | Raja Casablanca | - | Fello Star | 1:1 | ||
| H: 14.02.2010 | R: 28.02.2010 | Sieger: Raja Casablanca | ||||
| H | Sony de Elá Nguema | - | Petro Atlético | 2:3 | ||
| R | Petro Atlético | - | Sony de Elá Nguema | 6:1 | ||
| H: 14.02.2010 | R: 28.02.2010 | Sieger: Petro Atlético | ||||
| H | Sahel SC | - | Club Africain | 2:1 | ||
| R | Club Africain | - | Sahel SC | 1:0 | ||
| H: 14.02.2010 | R: 26.02.2010 | Sieger: Club Africain | ||||
| H | Gazelle FC | - | Bayelsa United | 1:0 | ||
| R | Bayelsa United | - | Gazelle FC | 2:2 | ||
| H: 14.02.2010 | R: 28.02.2010 | Sieger: Gazelle FC | ||||
| H | St. George SC | - | Al Merrikh SC | 1:1 | ||
| R | Al Merrikh SC | - | St. George SC | 3:1 | ||
| H: 14.02.2010 | R: 27.02.2010 | Sieger: Al Merrikh SC | ||||
| H | AS Stade Mandji | - | ASFA Yennenga | 0:2 | ||
| R | ASFA Yennenga | - | AS Stade Mandji | 4:1 | ||
| H: 14.02.2010 | R: 28.02.2010 | Sieger: ASFA Yennenga | ||||
| H | La Passe FC | - | Curepipe Starlight SC | 1:0 | ||
| R | Curepipe Starlight SC | - | La Passe FC | 3:1 | ||
| H: 14.02.2010 | R: 28.02.2010 | Sieger: Curepipe Starlight SC | ||||
| H | Mafunzo | - | Gunners FC | 1:2 | ||
| R | Gunners FC | - | Mafunzo | 4:0 | ||
| H: 14.02.2010 | R: 28.02.2010 | Sieger: Gunners FC | ||||
| H | AS Tempête Mocaf | - | Al Ittihad Tripolis | 1:2 | ||
| R | Al Ittihad Tripolis | - | AS Tempête Mocaf | 6:0 | ||
| H: 14.02.2010 | R: 27.02.2010 | Sieger: Al Ittihad Tripolis | ||||
| H | URA SC | - | Zanaco FC | 1:0 | ||
| R | Zanaco FC | - | URA SC | 4:0 | ||
| H: 14.02.2010 | R: 27.02.2010 | Sieger: Zanaco FC | ||||
| H | Diables Noirs | - | ES Sétif | 3:2 | ||
| R | ES Sétif | - | Diables Noirs | 2:0 | ||
| H: 14.02.2010 | R: 27.02.2010 | Sieger: ES Sétif | ||||
| H | Mbabane Swallows | - | SuperSport United | 1:3 | ||
| R | SuperSport United | - | Mbabane Swallows | 2:2 | ||
| H: 14.02.2010 | R: 27.02.2010 | Sieger: SuperSport United | ||||
